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Comment
. 2008 Sep;6(9):e248.
doi: 10.1371/journal.pbio.0060248. Epub 2008 Sep 30.

A molecular link between albinism and visual deficits

Liza Gross
Comment

A molecular link between albinism and visual deficits

Liza Gross. PLoS Biol. 2008 Sep.
No abstract available

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Figures

None
An autocrine loop between OA1 and tyrosinase and linked through l-DOPA includes the secretion of at least one very potent retinal neurotrophic factor, PEDF. Changes in OA1 signaling may underlie the disruptions in retinal development that cause albinism-related vision problems.
See this image and copyright information in PMC

Comment on

  • L-DOPA is an endogenous ligand for OA1.
    Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS. Lopez VM, et al. PLoS Biol. 2008 Sep 30;6(9):e236. doi: 10.1371/journal.pbio.0060236. PLoS Biol. 2008. PMID: 18828673 Free PMC article.