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Review

. 2009 Dec 29;106(52):22035-6.

doi: 10.1073/pnas.0912300107. Epub 2009 Dec 23.

Regulating transcription regulators via allostery and flexibility

Dorothy Beckett¹

Affiliations

Affiliation

¹ Department of Chemistry and Biochemistry, Center for Biological Structure and Organization, University of Maryland, College Park, MD 20742-2021, USA. dbeckett@umd.edu

PMID: 20080782
PMCID: PMC2799754
DOI: 10.1073/pnas.0912300107

Review

Regulating transcription regulators via allostery and flexibility

Dorothy Beckett. Proc Natl Acad Sci U S A. 2009.

. 2009 Dec 29;106(52):22035-6.

doi: 10.1073/pnas.0912300107. Epub 2009 Dec 23.

Author

Dorothy Beckett¹

Affiliation

¹ Department of Chemistry and Biochemistry, Center for Biological Structure and Organization, University of Maryland, College Park, MD 20742-2021, USA. dbeckett@umd.edu

PMID: 20080782
PMCID: PMC2799754
DOI: 10.1073/pnas.0912300107

No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1. — Fig. 1.
Model of allosteric regulation of a conformationally flexible transcription regulatory protein. The unliganded or apo protein exits as an ensemble of energetically equivalent structures. Small ligand and DNA binding drive the protein to distinct conformational preferences.

See this image and copyright information in PMC

Comment on

The induction of folding cooperativity by ligand binding drives the allosteric response of tetracycline repressor.
Reichheld SE, Yu Z, Davidson AR. Reichheld SE, et al. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22263-8. doi: 10.1073/pnas.0911566106. Epub 2009 Dec 22. Proc Natl Acad Sci U S A. 2009. PMID: 20080791 Free PMC article.

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References

1. Reichheld SE, Yu Z, Davidson AR. The induction of folding cooperativity by ligand binding drives the allosteric response of tetracycline repressor. Proc Natl Acad Sci USA. 2009;106:22263–22268. - PMC - PubMed
1. Saenger W, Orth P, Kisker C, Hillen W, Hinrichs W. The tetracycline repressor: A paradigm for a biological switch. Angew Chem Int Ed Engl. 2000;39:2042–2052. - PubMed
1. Hinrichs W, et al. Structure of the Tet repressor–tetracycline complex and regulation of antibiotic resistance. Science. 1994;264:418–420. - PubMed
1. Orth P, et al. Conformational changes of the Tet repressor induced by tetracycline trapping. J Mol Biol. 1998;279:439–447. - PubMed
1. Orth P, Schnappinger D, Hillen W, Saenger W, Hinrichs W. Structural basis of gene regulation by the tetracycline-inducible Tet repressor–operator system. Nat Struct Biol. 2000;7:215–219. - PubMed

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