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Review
. 2010 Feb;51(2):169-72.
doi: 10.2967/jnumed.109.066878. Epub 2010 Jan 15.

In vivo imaging of RNA interference

Hao Hong  1 , Yin Zhang, Weibo Cai
Affiliations
Review

In vivo imaging of RNA interference

Hao Hong et al. J Nucl Med. 2010 Feb.

Abstract

RNA interference (RNAi), an effective technique for regulating or silencing specific genes, can be applied to treat various diseases. Multiple clinical trials using RNAi are ongoing, and molecular imaging can serve as a powerful tool in RNAi-based therapies. This brief review will highlight the current progress on in vivo imaging of RNAi delivery and silencing effects. Incorporation of suitable molecular imaging techniques into future RNAi-based clinical trials will provide more pieces of the puzzle, thus facilitating the transformation of RNAi into a powerful therapeutic modality in the clinic.

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Figures

Figure 1
Figure 1
Molecular imaging techniques can be used to monitor both gene delivery efficiency and the silencing effect of RNAi. In some cases the carriers can also be the image tags. Upon further optimization and rigorous validation, many of these techniques may be translated into the clinic in the future.
See this image and copyright information in PMC

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