[Contemporary opinions on pathogenesis, genetics and clinical picture of laterality disorders - left-right axis development defects]
- PMID: 20081278
[Contemporary opinions on pathogenesis, genetics and clinical picture of laterality disorders - left-right axis development defects]
Abstract
Congenital malformations pose a great challenge to all medical specialities. Laterality defects belong to the group of congenital anomalies resulting from left-right axis development disturbances which arise at an early stage of embryogenesis. The authors discuss selected embryological, epidemiological, genetic and clinical aspects of left-right axis malformations. Furthermore recent knowledge concerning new genes involved in left-right asymmetry development is presented.
Similar articles
-
Left-right lineage analysis of the embryonic Xenopus heart reveals a novel framework linking congenital cardiac defects and laterality disease.Development. 2006 Apr;133(7):1399-410. doi: 10.1242/dev.02292. Development. 2006. PMID: 16527986
-
Disorders of left-right asymmetry: heterotaxy and situs inversus.Am J Med Genet C Semin Med Genet. 2009 Nov 15;151C(4):307-17. doi: 10.1002/ajmg.c.30228. Am J Med Genet C Semin Med Genet. 2009. PMID: 19876930 Review.
-
Genetic basis of human left-right asymmetry disorders.Expert Rev Mol Med. 2015 Jan 27;16:e19. doi: 10.1017/erm.2014.22. Expert Rev Mol Med. 2015. PMID: 26258520 Review.
-
A case of complete situs inversus.Rev Port Cardiol. 2003 Jan;22(1):91-104. Rev Port Cardiol. 2003. PMID: 12712813 English, Portuguese.
-
Gene-dosage-sensitive genetic interactions between inversus viscerum (iv), nodal, and activin type IIB receptor (ActRIIB) genes in asymmetrical patterning of the visceral organs along the left-right axis.Dev Dyn. 2002 Jul;224(3):279-90. doi: 10.1002/dvdy.10103. Dev Dyn. 2002. PMID: 12112458