[Contemporary opinions on pathogenesis, genetics and clinical picture of laterality disorders - left-right axis development defects]
- PMID: 20081278
[Contemporary opinions on pathogenesis, genetics and clinical picture of laterality disorders - left-right axis development defects]
Abstract
Congenital malformations pose a great challenge to all medical specialities. Laterality defects belong to the group of congenital anomalies resulting from left-right axis development disturbances which arise at an early stage of embryogenesis. The authors discuss selected embryological, epidemiological, genetic and clinical aspects of left-right axis malformations. Furthermore recent knowledge concerning new genes involved in left-right asymmetry development is presented.