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Clinical Trial
. 2009 Nov;23 Suppl 1(Suppl 1):S89-95.
doi: 10.1097/01.aids.0000363781.50580.03.

Successful increase in contraceptive uptake among Kenyan HIV-1-serodiscordant couples enrolled in an HIV-1 prevention trial

Kenneth Ngure  1 , Renee Heffron, Nelly Mugo, Elizabeth Irungu, Connie Celum, Jared M Baeten
Affiliations
Clinical Trial

Successful increase in contraceptive uptake among Kenyan HIV-1-serodiscordant couples enrolled in an HIV-1 prevention trial

Kenneth Ngure et al. AIDS. 2009 Nov.

Abstract

Objective: To evaluate a multipronged approach to promote dual contraceptive use by women within heterosexual HIV-1-serodiscordant partnerships.

Methods: For 213 HIV-1-serodiscordant couples in Thika, Kenya, participating in an HIV-1 prevention clinical trial, contraceptive promotion was initiated through a multipronged intervention that included staff training, couples family planning sessions, and free provision of hormonal contraception on-site. Contraceptive use and pregnancy incidence were compared between two time periods (before versus after June 2007, when the intervention was initiated) and between Thika and other Kenyan trial sites (Eldoret, Kisumu, and Nairobi). Generalized estimating equations and Andersen-Gill proportional hazards modeling were used.

Results: Nonbarrier contraceptive use increased after implementation of the intervention: from 31.5 to 64.7% of visits among HIV-1-seropositive women [odds ratio 4.0, 95% confidence interval (CI) 3.0-5.3] and from 28.6 to 46.7% of visits among HIV-1-seronegative women (odds ratio 2.2, 95% CI 1.4-3.5). In comparison, at the other Kenyan sites, where the intervention was not implemented, contraceptive use changed minimally, from 15.6 to 22.3% of visits for HIV-1-seropositive women and from 13.6 to 12.7% among HIV-1-seronegative women. Self-reported condom use remained high during follow-up. Pregnancy incidence at the Thika was significantly lower after compared with before June 2007 (hazard ratio 0.2, 95% CI 0.1-0.6) and was approximately half that at other Kenyan sites during the intervention period (hazard ratio 0.5, 95% CI 0.3-0.8).

Conclusion: A multipronged family planning intervention can lead to high nonbarrier contraceptive uptake and reduced pregnancy incidence among women in HIV-1-serodiscordant partnerships.

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Figures

Figure 1
Figure 1
Non-condom contraceptive use prevalence by calendar month in Thika and other Kenyan sites, for a) HIV-1 seropositive and b) HIV-1 seronegative women.
Figure 1
Figure 1
Non-condom contraceptive use prevalence by calendar month in Thika and other Kenyan sites, for a) HIV-1 seropositive and b) HIV-1 seronegative women.
See this image and copyright information in PMC

References

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    1. National AIDS and STI Control Program (NASCOP), Ministry of Health (MOH), Kenya. Kenya AIDS Indicator Survey 2007: Preliminary Report. Nairobi, Kenya: Republic of Kenya; 2008.
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