Tipping the scale: muscle versus fat
- PMID: 20081844
- DOI: 10.1038/ncb0210-102
Tipping the scale: muscle versus fat
Erratum in
- Nat Cell Biol. 2010 Mar;12(3):306
Abstract
Adipocytes and scar tissue form during skeletal muscle degeneration. Two new studies reveal that adipocytes and fibroblasts in skeletal muscle derive from a population of bipotent progenitors that reside within muscle, but are not derived from the muscle lineage. These progenitor cells also have a surprising role in stimulating the restoration of muscle mass during regeneration.
Comment on
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Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis.Nat Cell Biol. 2010 Feb;12(2):153-63. doi: 10.1038/ncb2015. Epub 2010 Jan 17. Nat Cell Biol. 2010. PMID: 20081841 Free PMC article.
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Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle.Nat Cell Biol. 2010 Feb;12(2):143-52. doi: 10.1038/ncb2014. Epub 2010 Jan 17. Nat Cell Biol. 2010. PMID: 20081842
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