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Comment
. 2010 Feb;130(2):338-41.
doi: 10.1038/jid.2009.331.

Could aging human skin use a connective tissue growth factor boost to increase collagen content?

Noelynn Oliver  1 , Mark Sternlicht, Karin Gerritsen, Roel Goldschmeding
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Could aging human skin use a connective tissue growth factor boost to increase collagen content?

Noelynn Oliver et al. J Invest Dermatol. 2010 Feb.
Free article

Abstract

The roles of connective tissue growth factor (CTGF) and transforming growth factor-beta (TGF-beta), both well-known collagen production stimulators, were examined in skin aging. Aged skin and fibroblasts exhibited a coordinate decrease in CTGF, TGF-beta, and type I procollagen expression and content. CTGF knockdown and TGF-beta blockade in normal dermal fibroblasts reduced procollagen expression, whereas overexpressing CTGF increased procollagen by a TGF-beta/Smad signaling-dependent mechanism without involving Smad2/3.

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