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Randomized Controlled Trial
. 2011 Jan;15(1):19-28.
doi: 10.1007/s10995-009-0557-z.

Very preterm birth is reduced in women receiving an integrated behavioral intervention: a randomized controlled trial

Ayman A E El-Mohandes  1 , Michele Kiely, Marie G Gantz, M Nabil El-Khorazaty
Affiliations
Randomized Controlled Trial

Very preterm birth is reduced in women receiving an integrated behavioral intervention: a randomized controlled trial

Ayman A E El-Mohandes et al. Matern Child Health J. 2011 Jan.

Abstract

This study examines whether an integrated behavioral intervention with proven efficacy in reducing psycho-behavioral risks (smoking, environmental tobacco smoke exposure (ETSE), depression, and intimate partner violence (IPV)) in African-Americans is associated with improved pregnancy outcomes. A randomized controlled trial targeting risks during pregnancy was conducted in the District of Columbia. African-American women were recruited if reporting at least one of the risks mentioned above. Randomization to intervention or usual care was site and risk specific. Sociodemographic, health risk and pregnancy outcome data were collected. Data on 819 women, and their singleton live born infants were analyzed using an intent-to-treat approach. Bivariate analyses preceded a reduced logistical model approach to elucidate the effect of the intervention on the reduction of prematurity and low birth weight. The incidence of low birthweight (LBW) was 12% and very low birthweight (VLBW) was 1.6%. Multivariate logistic regression results showed that depression was associated with LBW (OR = 1.71, 95% CI = 1.12-2.62). IPV was associated with preterm birth (PTB) and very preterm birth (VPTB) (OR 1.64, 95% CI = 1.07-2.51, OR = 2.94, 95% CI = 1.40-6.16, respectively). The occurrence of VPTB was significantly reduced in the intervention compared to the usual care group (OR = 0.42, 95% CI = 0.19-0.93). Our study confirms the significant associations between multiple psycho-behavioral risks and poor pregnancy outcomes, including LBW and PTB. Our behavioral intervention with demonstrated efficacy in addressing multiple risk factors simultaneously reduced VPTB within an urban minority population.

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Figure 1
Profile of Project DC-HOPE Randomized Controlled Trial
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References

    1. Mathews TJ, MacDorman MF. National vital statistics reports. 2. Vol. 57. Hyattsville, MD: National Center for Health Statistics; 2008. Infant mortality statistics from the 2005 period linked birth/infant death data set. - PubMed
    1. Callaghan WM, MacDorman MF, Rasmussen SA, Qin C, Lakritz EM. The contribution of preterm birth to infant mortality rates in the United States. Pediatrics. 2006;118(4):1566–1573. - PubMed
    1. Dominguez TP. Race, racism, and racial disparities in adverse birth outcomes. Clinical Obstetrics and Gynecology. 2008;51:360–370. - PubMed
    1. Reagan PB, Salsberry PJ. Race and ethnic differences of preterm birth in the USA: Broadening the social context. Social Science & Medicine. 2005;60:2217–2228. - PubMed
    1. Serenius F, Ewald U, Farooqi A, Holmgren PA, Hakansson S, Sedin G. Short-term outcome after active perinatal management at 23–25 weeks of gestation. A study from two Swedish tertiary care centres. Part 1: maternal and obstetric factors. Acta Paediatrica. 2004;93(7):945–953. - PubMed

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