Review
doi: 10.1016/j.coi.2009.12.005.
Epub 2010 Jan 18.
TLR signalling regulated antigen presentation in dendritic cells
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- PMID: 20083398
- DOI: 10.1016/j.coi.2009.12.005
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Review
TLR signalling regulated antigen presentation in dendritic cells
Curr Opin Immunol.
2010 Feb.
Abstract
Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, PI3-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC.
Copyright 2009 Elsevier Ltd. All rights reserved.
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