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Case Reports
. 2010 Jan 19;74(3):265-7.
doi: 10.1212/WNL.0b013e3181cb3e52.

Reversible paraneoplastic limbic encephalitis associated with antibodies to the AMPA receptor

L Bataller  1 , R Galiano, M García-Escrig, B Martínez, T Sevilla, R Blasco, J J Vílchez, J Dalmau
Affiliations
Case Reports

Reversible paraneoplastic limbic encephalitis associated with antibodies to the AMPA receptor

L Bataller et al. Neurology. .
No abstract available

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Figures

None
Figure GluR2 antibody specificity and expression of GluR2 in the patient's tumor (A) Reactivity of patient's CSF (diluted 1:10) with nonpermeabilized cultures of rat hippocampal neurons developed with immunofluorescence (×800). Note the intense immunolabeling of the neuronal cell surface. (B, C) Patient's tumor immunolabeled with patient's biotinylated immunoglobulin G (IgG) (B) and a mouse monoclonal antibody against GluR2 (MAB397, Chemicon) (C) developed with immunoperoxidase (×200). Note the similar pattern of reactivities between the patient's IgG and the GluR2 antibody. No reactivity was detected with IgG from a normal individual (not shown). (D, E) Immunofluorescence of HEK293 cells (×400) transfected with GluR2 reacting with the GluR2 monoclonal antibody (D) and the patient's antibody (E). Merged reactivities are shown in (F). All techniques used for these studies have been previously reported by the authors.
See this image and copyright information in PMC

References

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    1. Graus F, Saiz A, Lai M, et al. Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associations. Neurology 2008;7:1930–1936. - PMC - PubMed

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