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Review

. 2010 Feb;11(2):101-4.

doi: 10.1038/ni0210-101.

The right team at the right time to go for a home run: tyrosine kinase activation by the TCR

Affiliations

Affiliation

¹ Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Departments of Medicine and of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA. aweiss@medicine.ucsf.edu

PMID: 20084063
DOI: 10.1038/ni0210-101

Review

The right team at the right time to go for a home run: tyrosine kinase activation by the TCR

Arthur Weiss. Nat Immunol. 2010 Feb.

. 2010 Feb;11(2):101-4.

doi: 10.1038/ni0210-101.

Author

Affiliation

¹ Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Departments of Medicine and of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA. aweiss@medicine.ucsf.edu

PMID: 20084063
DOI: 10.1038/ni0210-101

Abstract

The TCR signals via cytoplasmic tyrosine kinases. Art Weiss recounts discoveries that led to early understanding of these events.

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References

1. Nature. 1985 Aug 15-21;316(6029):606-9 - PubMed
1. Cell. 1991 Mar 8;64(5):1037-46 - PubMed
1. Nature. 1984 Mar 8-14;308(5955):149-53 - PubMed
1. Nature. 1990 Jul 5;346(6279):66-8 - PubMed
1. Science. 1990 Mar 30;247(4950):1584-7 - PubMed

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