MicroTUB(B3)ules and brain development
- PMID: 20085703
- DOI: 10.1016/j.cell.2009.12.038
MicroTUB(B3)ules and brain development
Abstract
The microtubule network is crucial for the developing nervous system, and mutations in tubulin-encoding genes disrupt neuronal migration. Tischfield et al. (2010) now report that mutations in the tubulin-encoding gene TUBB3 have a striking impact on microtubule dynamics in neurons, resulting in a diverse set of disease symptoms.
Comment on
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Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.Cell. 2010 Jan 8;140(1):74-87. doi: 10.1016/j.cell.2009.12.011. Cell. 2010. PMID: 20074521 Free PMC article.
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