Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jun;51(6):1478-85.
doi: 10.1194/jlr.M003509. Epub 2010 Jan 19.

The relative atherogenicity of VLDL and LDL is dependent on the topographic site

Eline Van Craeyveld  1 , Frank Jacobs, Yingmei Feng, Leen C J Thomassen, Johan A Martens, Joke Lievens, Jan Snoeys, Bart De Geest
Affiliations

The relative atherogenicity of VLDL and LDL is dependent on the topographic site

Eline Van Craeyveld et al. J Lipid Res. 2010 Jun.

Abstract

To evaluate whether the relative atherogenicity of VLDL and LDL is dependent on the topographic site, atherosclerosis was compared at four topographic sites in homozygous LDL receptor (LDLr)-deficient rabbits fed normal chow and in heterozygous LDLr-deficient rabbits with the same genetic background fed a 0.15% cholesterol diet to match cholesterol levels. VLDL cholesterol was significantly higher and LDL cholesterol significantly lower in LDLr(+/-) diet rabbits compared with LDLr(-/-) rabbits. Intimal area in the ascending thoracic aorta and in the abdominal aorta at the level of the renal arteries was 1.4-fold (P < 0.05) and 1.5-fold (P < 0.05) higher, respectively, in LDLr(-/-) rabbits than in LDLr(+/-) diet rabbits, whereas no significant difference occurred in the descending thoracic aorta and in the abdominal aorta just above the bifurcation. Differences remained statistically significant after adjustment for plasma cholesterol, triglycerides, and sex. Compared with LDLr(+/-) diet rabbits, higher intimal lipoprotein lipase (LPL) and apolipoprotein (apo) B levels were observed in LDLr(-/-) rabbits only at the level of the descending thoracic aorta. Intimal apo E levels in LDLr(-/-) rabbits were significantly lower in sites with a larger intima than in LDLr(+/-) diet rabbits. In conclusion, the relative atherogenicity of VLDL and LDL is dependent on the topographic site.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Representative hematoxylin and eosin stained sections of the ascending thoracic aorta (A, B), the descending thoracic aorta (C, D), the abdominal aorta at the level of the renal arteries (E, F), and the abdominal aorta just above the bifurcation (G, H) in heterozygous LDLr-deficient rabbits fed a 0.15% cholesterol diet (left panels) and in homozygous LDLr-deficient rabbits (right panels).
See this image and copyright information in PMC

References

    1. Lusis A. J. 2000. Atherosclerosis. Nature. 407: 233–241. - PMC - PubMed
    1. Hutter C. M., Austin M. A., Humphries S. E. 2004. Familial hypercholesterolemia, peripheral arterial disease, and stroke: a HuGE minireview. Am. J. Epidemiol. 160: 430–435. - PubMed
    1. Twickler T., Dallinga-Thie G. M., Chapman M. J., Cohn J. S. 2005. Remnant lipoproteins and atherosclerosis. Curr. Atheroscler. Rep. 7: 140–147. - PubMed
    1. Proctor S. D., Vine D. F., Mamo J. C. 2002. Arterial retention of apolipoprotein B(48)- and B(100)-containing lipoproteins in atherogenesis. Curr. Opin. Lipidol. 13: 461–470. - PubMed
    1. Tabas I., Williams K. J., Boren J. 2007. Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation. 116: 1832–1844. - PubMed

Publication types