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Randomized Controlled Trial
. 2010 Mar;27(2):127-35.
doi: 10.1007/s10840-009-9454-z. Epub 2010 Jan 20.

Prospective multicenter randomized trial of fast ventricular tachycardia termination by prolonged versus conventional anti-tachyarrhythmia burst pacing in implantable cardioverter-defibrillator patients-Atp DeliVery for pAiNless ICD thErapy (ADVANCE-D) Trial results

Massimo Santini  1 , Maurizio Lunati, Pascal Defaye, Johann Mermi, Alessandro Proclemer, Silvia del Castillo-Arroys, Giulio Molon, Elisabetta Santi, Tiziana De Santo, Xavier Navarro, Axel Kloppe
Affiliations
Randomized Controlled Trial

Prospective multicenter randomized trial of fast ventricular tachycardia termination by prolonged versus conventional anti-tachyarrhythmia burst pacing in implantable cardioverter-defibrillator patients-Atp DeliVery for pAiNless ICD thErapy (ADVANCE-D) Trial results

Massimo Santini et al. J Interv Card Electrophysiol. 2010 Mar.

Erratum in

  • J Interv Card Electrophysiol. 2010 Oct;29(1):73

Abstract

Purpose: The purpose of the trial was to quantify and compare the efficacy of two different sequences of burst anti-tachycardia pacing (ATP) strategies for the termination of fast ventricular tachycardia.

Methods: The trial was prospective, multicenter, parallel and randomized, enrolling patients with an indication for implantable cardioverter-defibrillator implantation.

Results: From February 2004, 925 patients were randomized and followed-up for 12 months. Eight pulses ATP terminated 64% of episodes vs. 70% in the 15-pulse group (p = 0.504). Fifteen pulses proved significantly better in patients without a previous history of heart failure (p = 0.014) and in patients with LVEF >or= 40% (p = 0.016). No significant differences between groups were observed with regard to syncope/near-syncope occurrence.

Conclusion: In the general population, 15-pulse ATP is as effective and safe as eight-pulse ATP. The efficacy of ATP on fast ventricular arrhythmias confirmed once more the striking importance of careful device programming in order to reduce painful shocks.

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Figures

Fig. 1
Fig. 1
Detection intervals and therapy programming description
Fig. 2
Fig. 2
ERB adjudication of episodes detected by ICD as spontaneous ventricular tachyarrhythmia. Details on the treatments delivered for episodes appropriately and inappropriately detected in the FVT window are reported. Not treated episodes that did not received any treatment. ATP only episodes treated only by ATP. Shock episodes treated with at least one shock
See this image and copyright information in PMC

References

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