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Review
. 2010 Feb;11(2):207-13.
doi: 10.1517/14656560903439737.

Pharmacotherapy for end-stage coronary artery disease

Neel R Sodha  1 , Louis M Chu, Munir Boodhwani, Frank W Sellke
Affiliations
Review

Pharmacotherapy for end-stage coronary artery disease

Neel R Sodha et al. Expert Opin Pharmacother. 2010 Feb.

Abstract

Importance of the field: Coronary artery disease remains the leading cause of mortality in the industrialized world. Despite advances in surgical and catheter-based interventions, a select number of patients remain with no options for invasive therapy. The goal of this review is to discuss the current status of pharmacotherapeutic interventions to treat end-stage coronary artery disease.

Areas covered in this review: Literature review on the topic of therapeutic angiogenesis from 1980 to 2009.

What the reader will gain: Insight into current therapeutic strategies employed to manage end-stage coronary artery disease.

Take home message: A promising approach focuses on augmenting the endogenous angiogenic response to chronic myocardial ischemia via the use of growth factors.

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Conflict of interest statement

Declaration of interest

N R Sodha is supported by National Institutes of Health grant T-32HL076130-02 and the Irving Bard Memorial Fellowship. F W Sellke is supported by RO1 HL69024 andRO1 HL46716. L M Chu is supported by the Irving Bard Memorial Fellowship. M Boodhwani is supported by National Institutes of Health grant HL04095-06 and the Irving Bard Memorial Fellowship.

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