Current review of Brugada syndrome: from epidemiology to treatment

Abstract

Brugada syndrome is a genetic cause of sudden cardiac arrest characterized by abnormal electrocardiographic (ECG) pattern in the right precordial leads either at rest or after provocation. In this condition, sudden death may occur due to polymorphic ventricular tachycardia or ventricular fibrillation. In approximately 30% of patients, sudden cardiac arrest is the initial clinical manifestation of Brugada syndrome. Treatment strategies for Brugada syndrome are evolving. Currently, the implanted cardioverter defibrillator (ICD) is the only proven treatment for Brugada syndrome. Candidates for ICD include patients include those with the type 1 ECG pattern or who have been successfully resuscitated from sudden death or have had unexplained syncope.