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. 2010 Jun;51(6):2872-7.
doi: 10.1167/iovs.08-2956. Epub 2010 Jan 20.

Blood pressure, perfusion pressure, and open-angle glaucoma: the Los Angeles Latino Eye Study

Farnaz Memarzadeh  1 , Mei Ying-Lai, Jessica Chung, Stanley P Azen, Rohit Varma; Los Angeles Latino Eye Study Group
Collaborators, Affiliations

Blood pressure, perfusion pressure, and open-angle glaucoma: the Los Angeles Latino Eye Study

Farnaz Memarzadeh et al. Invest Ophthalmol Vis Sci. 2010 Jun.

Abstract

Purpose: To examine the cross-sectional relationship between blood pressure, perfusion pressure, and prevalence of open angle glaucoma (OAG) in an adult Latino population.

Methods: Participants aged 40 years and older (N = 6130) from the Los Angeles Latino Eye Study (LALES), a large, population-based study of self-identified adult Latinos, underwent an interviewer-administered questionnaire and a complete ocular and clinical examination. Logistic regression was used to evaluate the covariate-adjusted association of OAG with systolic, diastolic, and mean blood pressures and perfusion pressures. Covariates included age, intraocular pressure, history of glaucoma treatment including medications and surgery, and history of blood pressure and treatment of blood pressure including use of medications.

Results: Low systolic (odds ratio [OR] = 2.5), diastolic (OR = 1.9), and mean (OR = 3.6) perfusion pressures and low diastolic blood pressure (OR = 1.9) were associated with a higher prevalence of OAG in LALES participants. Higher systolic blood pressure and mean arterial blood pressure were associated with a higher prevalence of OAG. There was no relationship between the prevalence of OAG and the presence of a history of cardiovascular disease.

Conclusions: Low diastolic, systolic and mean perfusion pressures, low diastolic blood pressure, and high systolic and mean arterial blood pressures are associated with a higher prevalence of OAG in adult Latinos.

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Figures

Figure 1.
Figure 1.
The relationship between systolic blood pressure (SBP) and the predicted prevalence of open-angle glaucoma (OAG) in participants in the Los Angeles Latino Eye Study. The locally weighted regression plot illustrates the independent relationship between SBP and the prevalence of OAG after adjustment for covariates.
Figure 2.
Figure 2.
The relationship between diastolic blood pressure (DBP) and the predicted prevalence of open-angle glaucoma (OAG) in participants of the Los Angeles Latino Eye Study. The locally weighted regression plot illustrates the independent relationship between DBP and prevalence of OAG after adjustment for covariates.
Figure 3.
Figure 3.
The relationship between mean arterial blood pressure (MABP) and the predicted prevalence of open-angle glaucoma (OAG) in participants of the Los Angeles Latino Eye Study. The locally weighted regression plot illustrates the independent relationship between MABP and prevalence of OAG after adjustment for covariates.
Figure 4.
Figure 4.
The relationship between diastolic perfusion pressure (DPP) and the predicted prevalence of open-angle glaucoma (OAG) in participants of the Los Angeles Latino Eye Study. The locally weighted regression plot illustrates the independent relationship between DPP and prevalence of OAG after adjustment for covariates.
Figure 5.
Figure 5.
The relationship between mean perfusion pressure (MPP) and the predicted prevalence of open-angle glaucoma (OAG) in participants of the Los Angeles Latino Eye Study. The locally weighted regression plot illustrates the independent relationship between MPP and prevalence of OAG after adjustment for covariates.
See this image and copyright information in PMC

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