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Comparative Study
. 2010;114(4):c277-87.
doi: 10.1159/000276580. Epub 2010 Jan 20.

Sleep quality, mood, alertness and their variability in CKD and ESRD

Maria-Eleni Roumelioti  1 , Christos Argyropoulos, Daniel J Buysse, Harry Nayar, Steven D Weisbord, Mark L Unruh
Affiliations
Comparative Study

Sleep quality, mood, alertness and their variability in CKD and ESRD

Maria-Eleni Roumelioti et al. Nephron Clin Pract. 2010.

Abstract

Background/aims: Little is known about the association of chronic kidney disease (CKD) with sleep quality, mood, and alertness. In this report, we assessed these symptoms among patients with advanced CKD (stages 4-5) and those with end-stage renal disease (ESRD) and compared them to healthy controls without known kidney disease.

Methods: Patients were recruited from local dialysis units, outpatient nephrology clinics and the Thomas E. Starzl Transplant Institute. Healthy control subjects matched for age, gender and race were drawn from an archival database. Daily symptoms of sleep quality, mood, and alertness were assessed by visual analogue scales of the Pittsburgh Sleep Diary. Health-related quality of life was assessed by the Short Form-36 instrument.

Results: Sixty-nine dialysis patients and 23patients with advanced CKD demonstrated worse scores in sleep quality, mood, and alertness (p < 0.001) than controls. In adjusted analyses, European-American race, dialysis dependency, younger age, and physical performance SF-36 components were significantly associated with poor sleep quality, mood and alertness (p < 0.05). The dialysis population demonstrated higher day-to-day variability in scores than either the advanced CKD patients or the controls.

Conclusion: Advanced CKD and dialysis dependency are associated with impaired and highly variable sleep quality, mood, and alertness.

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Figures

Fig. 1
Fig. 1
Mean and standard deviation of mood, sleep quality, and alertness in patients and controls. • = Average score. Error bar represents standard deviation of the score in each domain (mood, sleep quality and alertness). Number of observations: 651 (controls), 308 (stage 4–5 CKD) and 880 (ESRD).
Fig. 2
Fig. 2
Day-to-day variability in mood, sleep quality, and alertness in patients and controls. Mean and standard deviation of each of the 3 domain scores by day of the study are presented. • = Mean score in each day. Error bar represents standard deviation of the score computed over all patients completing the diary each day.
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