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. 2010 Feb 7;8(3):529-32.
doi: 10.1039/b918214d. Epub 2009 Nov 26.

(-)-Bacillamide C: the convergent approach

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(-)-Bacillamide C: the convergent approach

Wei Wang et al. Org Biomol Chem. .

Abstract

The newly discovered natural product bacillamide C and several derivatives were convergently synthesized for the first time and in only three steps. The key transformation constitutes a thiazole Ugi multicomponent reaction. These compounds will serve to elucidate chemical biology and SAR of this potent anti-algae natural product and shows the synthetic pathway to related natural products.

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