Acupuncture for uterine fibroids
- PMID: 20091625
- PMCID: PMC11270531
- DOI: 10.1002/14651858.CD007221.pub2
Acupuncture for uterine fibroids
Abstract
Background: Uterine fibroids (UFs) are benign growths within the uterine muscle and are present in 30% of women during their reproductive years. With the exception of hysterectomy, there are no effective medical and surgical treatments for women with uterine fibroids . Acupuncture is an ancient Chinese method which has been used for both the prevention and treatment of diseases for over three thousand years. There are many types of acupuncture used to manage UFs, with body acupuncture being the most commonly used. The literature reporting the benefits or harms of acupuncture for the management of UFs has not yet been systematically reviewed.
Objectives: To assess the benefits and harms of acupuncture in women with uterine fibroids
Search strategy: The following electronic databases were searched 21st May 2009: the Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; AMED; the Menstrual Disorders and Subfertility Group's Specialised Register of Trials; Chinese Biomedical Literature Database (CBM); Traditional Chinese Medical Literature Analysis and Retrieval System (TCMLARS); Chinese Medical Current Contents (CMCC) and China National Knowledge Infrastructure(CNKI). Citation lists, experts in the field and grey literature were also referred to. No restrictions such as language were applied.
Selection criteria: All randomised controlled trials (RCTs) comparing acupuncture management with placebo acupuncture, no management, Chinese medication, Western medication or other managements of uterine fibroids were considered for inclusion. Acupuncture management included either traditional acupuncture or contemporary acupuncture, regardless of the source of stimulation (for example, body, electro, scalp, elongated, fire, hand, fine needle, moxibustion). Acupuncture management without needling was excluded.
Data collection and analysis: Two review authors assessed trial risk of bias according to our a priori criteria. No trials were included in this version of the review, therefore no data was collected.
Main results: No randomized double-blind controlled trials met the inclusion criteria .
Authors' conclusions: The effectiveness of acupuncture for the management of uterine fibroids remains uncertain. More evidence is required to establish the efficacy and safety of acupuncture for uterine fibroids.There is a continued need for well designed RCTs with long term follow up.
Conflict of interest statement
None known
Update of
- doi: 10.1002/14651858.CD007221
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References
References to studies excluded from this review
Deng 2008 {published data only}
-
- Deng J, Zhao ZJ. The Integrative Method of Chuang Medicine for Uterine Fibroids. Journal of Chinese Ethical Medicine 2008;9(9):2‐3. [1006‐6810(2008)09‐0002‐02]
Engman 2008 {published data only}
-
- Engman M, Skoog L, Soderqvist G, Gemzell‐Danielsson K. The effect of mifepristone on breast cell proliferation in premenopausal women evaluated through fine needle aspiration cytology. Human reproduction (Oxford, England) 2008;23(9):2072‐2079. - PubMed
Hamza 1999 {published data only}
-
- Hamza MA, White PF, Ahmed HE, Ghoname EA. Effect of the frequency of transcutaneous electrical nerve stimulation on the postoperative opioid analgesic requirement and recovery profile. Anesthesiology 1999;91(5):1232‐1238. - PubMed
Wang 2005 {published data only}
-
- Wang W, Chen Y. Clinical study on dry cough relating to the throat treated at Ding‐chuan acupoint injection. Journal of Clinical Acupuncture and Moxibustion 2005;21(8):3. [1005‐0779(2005)08‐0003‐01]
Yu 2005 {published data only}
-
- Yu L, Zhang CT, Cao XM. The Clinical Observation of Warm Needle (EX‐CA1) for Uterine Fibroids. Journal of Clinical Acupuncture and Moxibustion 2005;21(9):45.
Zhao 1999 {published data only}
-
- Zhao YX. The Application of Warm Needle Equipment for Gynecological postoperative exsufflation. Shanghai Journal of Acupuncture and Moxibustion 1999;18(3):16.
Additional references
ACOG 1994
-
- Uterine leiomyomata. American College of Obstetricians and Gynecologists (ACOG) Technical Bulletin. 1994, issue 192.
Alan 2005
-
- Arslan AA, Gold LI, Mittal K, Suen TC, Belitskaya‐Levy I, Tang MS, et al. Gene expression studies provide clues to the pathogenesis of uterine leiomyoma: new evidence and a systematic review. Human Reproduction 2005;20(4):852‐63. - PubMed
Albano 2001
-
- Albano C, Platteau P, Devroey P. Gonadotropinreleasing hormone antagonist: how good is the new hope?. Current Opinion in Obstetrics and Gynecology 2001;13:257‐62. - PubMed
Andersen 1998
-
- Andersen J. Factors in fibroid growth. Baillières Clinical Obstetrics and Gynaecology 1998;12:225‐43. - PubMed
Ang 2001
-
- Ang WC, Farrell E, Vollenhoven B. Effect of hormone replacement therapies and selective estrogen receptor modulators in postmenopausal women with uterine leiomyomas: a literature review. Climacteric 2001;4:284‐92. - PubMed
Benecke 2005
-
- Benecke C, Kruger TF, Siebert TI, Merwe JP, Steyn DW. Effect of fibroids on fertility in patients undergoing assisted reproduction. Gynecological and Obstetrics Investigation 2005;59:225‐30. - PubMed
Chen 2001
-
- Chen CR, Buck GM, Courey NG, Perez KM, Wactawski‐Wende J. Risk factors for uterine fibroids among women undergoing tubal sterilization. American Journal of Epidemiology 2001;153(1):20‐6. - PubMed
Chiaffarino 1999
-
- Chiaffarino F, Parazzini F, Vecchia C, Marsico S, Surace M, Ricci E. Use of oral contraceptives and uterine fibroids: results of a case‐control study.. British Journal Obstetrics and Gynaecology 1999;106:857‐60. - PubMed
Clarke 1995
-
- Clarke A, Black N, Rowe P, Mott S, Howle K. Indications for and outcome of total abdominal hysterectomy for benign disease: a prospective cohort study.. British Journal of Obstetrics and Gynaecology 1995;102:611‐20. - PubMed
Coutinho 1989
-
- Coutinho EM, Goncalves MT. Long‐term treatment of leiomyomas with gestrinone. Fertility and Sterility 1989;51:939‐46. - PubMed
David 2005
-
- David M, Ebert AD. Treatment of uterine fibroids by embolization‐‐advantages, disadvantages, and pitfalls. European Journal of Obstetrics, Gynecology, and Reproductive Biology 2005;123:131‐8. [MEDLINE: ] - PubMed
De Leo 1997
-
- Leo V, Morgante G, Lanzetta D, DAntona D, Bertieri RS. Danazol administration after gonadotropin‐releasing hormone analogue reduces rebound of uterine myomas. Human Reproduction 1997;12:357‐60. - PubMed
DeCherney 1983
-
- DeCherney AH, Maheux R, Polan ML. A medical treatment for myomata uteri. Fertility and Sterility 1983;39:429‐30.
Duncan 2001
-
- Rougier‐Chapman DP, Key SM, Ryan JM. Uterine artery embolization for the treatment of symptomatic fibroid disease. Applied Radiology 2001;September:11‐7.
Edwards 2007
-
- Edwards RD, Moss JG, Lumsden MA, Wu O, Murray LS, Twaddle S, et al. Uterine‐artery embolization versus surgery for symptomatic uterine fibroids. New England Journal of Medicine 2007;356(4):360‐70. - PubMed
Faerstein 2001
-
- Faerstein E, Szklo M, Rosenshein N. Risk factors for uterine leiomyoma: a practice‐based case‐control study. I. African‐American heritage, reproductive history, body size, and smoking.. American Journal of Epidemiology 2001;153:1‐10. - PubMed
Farquhar 2000
-
- Farquhar C, Arroll B, Ekeroma A, Fentiman G, Rademaker L, Roberts H, et al. An evidence‐based guideline for the management of uterine fibroids [New Zealand Guidelines Group]. http://www.nzgg.org.nz/guidelines/0063/050623_Uterine_Fibroids_refreshed... 2000. - PubMed
Flower 2009
Friedman 1995
-
- Friedman AJ, Thomas PP. Does low‐dose combination oral contraceptive use affect uterine size or menstrual flow in premenopausal women with leiomyomas?. Obstetrics and Gynecology 1995;85:631‐5. - PubMed
Fugh‐Berman 2004
-
- Fugh‐Berman A, Balick MJ, Kronenberg F, Ososki AL, O'Connor B, Reiff M, et al. Treatment of fibroids: the use of beets (Beta vulgaris) and molasses (Saccharum officinarum) as an herbal therapy by Dominican healers in New York City.. Journal of Ethnopharmacology 2004;92(23):337‐9. - PubMed
Grigorieva 2003
-
- Grigorieva V, Chen‐Mok M, Tarasova M, Mikhailov A. Use of a levonorgestrel‐releasing intrauterine system to treat bleeding related to uterine leiomyomas. Fertility and Sterility 2003;79(5):1194‐8. - PubMed
Gupta 2006
Helene 2001
-
- Langevin HM, Churchill DL, Cipolla MJ. Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture. The FASEB Journal 2001;15:2275‐82. - PubMed
Higgins 2008 [Computer program]
-
- Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0. Version Version 5.0.0. Cochrane collaboration, February 2008.
Huang 2003
-
- Huang YY. Research advance and prospects of traditional Chinese medicine and western medicine for treatment of uterine fibroids. Tianjin Journal of Traditional Chinese Medicine 2003;20(6):78‐80.
Huirne 2001
-
- Huirne JA, Lambalk CB. Gonadotropin‐releasinghormone‐receptor antagonists. Lancet 2001;358:1793‐1803. - PubMed
Imai 2003
-
- Imai A, Sugiyama S, Furui T, Tamaya T. Treatment of perimenopausal women with uterine myoma: successful use of a depot GnRH agonist leading to a natural menopause. Journal of Obstetrics and Gynaecology 2003;23(5):518‐820. - PubMed
Johansson 1993
-
- Johansson K, Lindgren I, Widner H, Wiklund I, Johansson BB. Can sensory stimulation improve the functional outcome in stroke patients?. Neurology 1993;43:2189‐92. - PubMed
Kaptchuk 2002
-
- Kaptchuk TJ. Acupuncture: theory, efficacy, and practice.. Annals of Internal Medicine 2002;136(5):374‐83. - PubMed
Kevin 2001
-
- Houston KD, Hunter DS, Hodges LC, Walker CL. Uterine leiomyomas: mechanisms of tumorigenesis. Toxiocologic Pathology 2001;29(1):100‐4. - PubMed
Lan 1997
-
- Lan FL, Li D. The development of study on Acupuncture for uterine fibroids. Journal of clinical acupuncture and moxibustion 1997;13(10):51‐3.
Langevin 2002
-
- Langevin HM, Churchill DL, Wu J, Badger GJ, Yandow JA, Fox JR, Krag MH. Evidence of connective tissue involvement in acupuncture. FASEB J 2002;16(8):872‐4. - PubMed
Lethaby 2001
-
- Lethaby A, Vollenhoven B, Sowter M. Pre‐operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids. Cochrane Database of Systematic Reviews 2001, Issue 2. - PubMed
Lo 2003
-
- Lo YL, Cui SL. Acupuncture and the modulation of cortical excitability. Neuroreport 2003;14(9):1229‐31. - PubMed
Lu 2000
-
- Lu JP, Cui YL, Shi RH. Chinese acupuncture and moxibustion. In: Zhang EQ editor(s). A Practical English‐Chinese Library of Traditional Chinese Medicine.. 8th Edition. ShangHai: unknown, 2000:21‐39, 428‐31.
Lumbiganon 1996
-
- Lumbiganon P, Rugpao S, Phandhu‐fung S, Laopaiboon M, Vudhikamraksa N, Werawatakul Y. Protective effect of depot‐medroxyprogesterone acetate on surgically treated uterine leiomyomas: a multicentre case‐control study.. British Journal of Obstetrics and Gynaecology 1996;103:909‐14. - PubMed
Lumsden 1998
-
- Lumsden MA, Wallace EM. Clinical presentation of uterine fibroids. Baillières Clinical Obstetrics and Gynaecology 1998;12:177‐95. - PubMed
Luoto 2000
-
- Luoto R, Kaprio J, Rutanen EM, Taipale P, Perola M, Koskenvuo M. Heritability and risk factors of uterine fibroids ‐ the Finnish Twin Cohort study. Maturitas 2000;37(1):15‐26. [PMID: 11099869] - PubMed
Marshall 1997
-
- Marshall LM, Spiegelman D, Barbieri RL, Goldman MB, Manson JE, Colditz GA. Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstetrics and Gynecology 1997;90:967‐73. - PubMed
Marshall 1998
-
- Marshall LM, Spiegelman D, Goldman MB, Manson JE, Colditz GA, Barbieri R. A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata.. Fertility and Sterility 1998;70:432‐39. - PubMed
Maruo 2004
-
- Maruo T, Ohara N, Wang J, MatsuoH. Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Human Reproduction Update 2004;10(3):207‐20. - PubMed
Meilahn 1989
-
- Meilahn EN, Matthews KA, Egeland G, Kelsey SF. Characteristics of women with hysterectomy. Maturitas 1989;11:319‐29. - PubMed
Moffet 2006
NIH 1998
-
- Acupuncture. [NIH Consensus Conference]. Journal of American Medical Association 1998; Vol. 280:1518‐24.
Rein 1995
-
- Rein MS, Barbieri RL, Friedman AJ. Progesterone: a critical role in the pathogenesis of uterine myomas.. American Journal of Obstetrics and Gynecology 1995;172:14‐8. - PubMed
Reiter 1992
-
- Reiter RC, Wagner PL, Gambone JC. Routine hysterectomy for large asymptomatic uterine leiomyomata: a reappraisal.. Obstetrics and Gynecology 1992;79(4):481‐4. - PubMed
Samadi 1996
Shikora 1991
-
- Shikora SA, Niloff JM, Bistrian BR. Relationship between obesity and uterine leiomyomata. Nutrition 1991;7:251‐5. - PubMed
Stewart 2001
-
- Stewart EA. Uterine fibroids. Lancet 2001;357:293‐8. - PubMed
Ueki 1995
-
- Ueki M, Okamoto Y, Tsurunaga T. Endocrinological and histological changes after treatment of uterine leiomyomas with Danazol or buserelin. Journal of Obstetrics and Gynecology 1995;27:1‐7. - PubMed
Ulett 1998
-
- Ulett GA, Han S, Han JS. Electroacupuncture: mechanisms and clinical application. Biological Psychiatry 1998;44(2):129‐38. - PubMed
Vercellini 1993
-
- Vercellini P, Vendola N, Ragni G, Trespidi L, Oldani S, Crosignani PG. Abnormal uterine bleeding associated with iron‐deficiency anemia: Etiology and role of hysteroscopy. Journal of Reproductive Medicine 1993;38:502‐4. - PubMed
Vollenhoven 1998
-
- Vollenhoven B. Introduction: the epidemiology of uterine leiomyomas.. Baillières Clinical Obstetrics and Gynaecology 1998;12:169‐76. - PubMed
WHO 1992
-
- WHO Scientific Group. Oral Contraceptives and Neoplasia [Geneva: World Health Organisation]. WHO Technical Report Series No 817. 1992:1‐46. - PubMed
Wu 1996
-
- Wu JN. A short history of acupuncture. Journal of Alternative and Complementary Medicine 1996;2:19‐21. - PubMed
Zhang 2003
-
- Zhang TM, Jia B, Liao CD. Chinese‐English Pocket Dictionary of Traditional Chinese Medicine. Beijing: People's Medical Publishing House, Feb 2003. [ISBN: 7‐117‐05266‐X/R 5267]
Zhao 2002
-
- Zhao JS, Liu YG, Hu K. Chinese acupuncture and Moxibustion. In: Zuo Yanfu editor(s). A Newly Compiled Practical English‐Chinese Library of Traditional Chinese Medicine. 59. ShangHai: Publishing house of Shanghai University of Traditional Chinese medicine, 2002:1‐2, 215‐7.
Zheng 2005
-
- Zheng YF, Jin L, Peng XC. Analysis on the incidence of hysteromyoma in 4386 women by gynecological mass screening. Women and children health care China 2005;20:542‐4.
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