Effects of excessive glucocorticoid receptor stimulation during early gestation on psychomotor and social behavior in the rat
- PMID: 20091810
- PMCID: PMC2855494
- DOI: 10.1002/dev.20419
Effects of excessive glucocorticoid receptor stimulation during early gestation on psychomotor and social behavior in the rat
Abstract
Severe psychological stress in the first trimester of pregnancy increases the risk of schizophrenia in the offspring. To begin to investigate the role of glucocorticoid receptors in this association, we determined the effects of the glucocorticoid dexamethasone (2 mg/kg), administered to pregnant rats on gestation days 6-8, on maternal behaviors and schizophrenia-relevant behaviors in the offspring. Dams receiving dexamethasone exhibited increased milk ejection bouts during nursing. Offspring of dexamethasone-treated dams (DEX) showed decreased juvenile social play and a blunted acoustic startle reflex in adolescence and adulthood, effects that were predicted by frequency of milk ejections in the dams. DEX offspring also showed increased prepulse inhibition of startle and reduced amphetamine-induced motor activity, effects not correlated with maternal behavior. It is postulated that over-stimulation of receptors targeted by glucocorticoids in the placenta or other maternal tissues during early gestation can lead to psychomotor and social behavioral deficits in the offspring. Moreover, some of these deficits may be mediated by alterations in postnatal maternal behavior and physiology produced by early gestational exposure to excess glucocorticoids.
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References
-
- Adams LA, Geyer MA. Effects of 6-hydroxydopamine lesions of locus coeruleus on startle in rats. Psychopharmacology. 1981;73(4):394–398. - PubMed
-
- Arnold JL, Siviy SM. Effects of neonatal handling and maternal separation on rough-and-tumble play in the rat. Developmental Psychobiology. 2002;41(3):205–215. - PubMed
-
- Baker S, Chebli M, Rees S, Lemarec N, Godbout R, Bielajew C. Effects of gestational stress: 1. Evaluation of maternal and juvenile offspring behavior. Brain Research. 2008;1213:98–110. - PubMed
-
- Barros VG, Rodriguez P, Martijena ID, Perez A, Molina VA, Antonelli MC. Prenatal stress and early adoption effects on benzodiazepine receptors and anxiogenic behavior in the adult rat brain. Synapse. 2006;60(8):609–618. - PubMed
-
- Beversdorf DQ, Manning SE, Hillier A, Anderson SL, Nordgren RE, Walters SE, et al. Timing of prenatal stressors and autism. Journal of Autism and Developmental Disorders. 2005;35(4):471–478. - PubMed
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