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Review
. 2010 Feb;20(1):41-50.
doi: 10.1016/j.gde.2009.12.001. Epub 2010 Jan 21.

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

Ling Huang  1 , Senthil K Muthuswamy
Affiliations
Review

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

Ling Huang et al. Curr Opin Genet Dev. 2010 Feb.

Abstract

In this review we discuss both gene expression and protein localization changes of polarity proteins in carcinoma. We highlight the importance of protein mislocalization and its possible role in cancer. We also discuss the emerging role of polarity proteins as regulators of proliferation, apoptosis, tissue polarity, epithelial-mesenchymal transition, in addition to their known role in cell junction biogenesis.

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Figures

Figure 1
Figure 1
Spatial distribution of polarity regulators in epithelial cells polarized along the apical-basal axis.
Figure 2
Figure 2
Emerging roles for polarity proteins: A, polarity pathways regulate cell proliferation [27,54,55]. B, polarity pathways regulate apoptosis [14,59,62]. C, polarity proteins regulate tissue polarity [58,63,64,66,68,77]. D, polarity pathways regulate cell migration and EMT [13,71-73,75].
See this image and copyright information in PMC

References

    1. Kumar V, Abbsa A, Fausto N, editors. Pathologic Basis of Disease. 7th. Elsevier Saunders; 1999. Neoplasia.
    1. Ivanov AI, Nusrat A, Parkos CA. Endocytosis of the Apical Junctional Complex: Mechanisms and Possible Roles in Regulation of Epithelial Barriers. Bioessays. 2005;27:356–365. - PubMed
    1. Simons M, Mlodzik M. Planar Cell Polarity Signaling: From Fly Development to Human Disease. Annu Rev Genet. 2008;42:517–540. - PMC - PubMed
    1. Knoblich JA. Mechanisms of Asymmetric Stem Cell Division. Cell. 2008;132:583–597. - PubMed
    1. Iden S, Collard JG. Crosstalk between Small Gtpases and Polarity Proteins in Cell Polarization. Nat Rev Mol Cell Bio. 2008;9:846–859. - PubMed

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