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Review
. 2010 Apr;149(1):1-9.
doi: 10.1016/j.virusres.2010.01.002. Epub 2010 Jan 20.

A systematic approach to virus-virus interactions

T DaPalma  1 , B P Doonan, N M Trager, L M Kasman
Affiliations
Review

A systematic approach to virus-virus interactions

T DaPalma et al. Virus Res. 2010 Apr.

Abstract

A virus-virus interaction is a measurable difference in the course of infection of one virus as a result of a concurrent or prior infection by a different species or strain of virus. Many such interactions have been discovered by chance, yet they have rarely been studied systematically. Increasing evidence suggests that virus-virus interactions are common and may be critical to understanding viral pathogenesis in natural hosts. In this review we propose a system for classifying virus-virus interactions by organizing them into three main categories: (1) direct interactions of viral genes or gene products, (2) indirect interactions that result from alterations in the host environment, and (3) immunological interactions. We have so far identified 15 subtypes of interaction and assigned each to one of these categories. It is anticipated that this framework will provide for a more systematic approach to investigating virus-virus interactions, both at the cellular and organismal levels.

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References

    1. Ackermann H.W., Kropinski A.M. Curated list of prokaryotic viruses with fully sequenced genomes. Res. Microbiol. 2007;158(7):555–566. - PubMed
    1. Agnello V., Abel G., Elfahal M., Knight G.B., Zhang Q.X. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc. Natl. Acad. Sci. U.S.A. 1999;96(22):12766–12771. - PMC - PubMed
    1. Andreoletti L., Hober D., Hober-Vandenberghe C., Fajardy I., Belaich S., Lambert V., Vantyghem M.C., Lefebvre J., Wattre P. Coxsackie B virus infection and beta cell autoantibodies in newly diagnosed IDDM adult patients. Clin. Diagn. Virol. 1998;9(2–3):125–133. - PubMed
    1. Arita M., Zhu S.L., Yoshida H., Yoneyama T., Miyamura T., Shimizu H. A Sabin 3-derived poliovirus recombinant contained a sequence homologous with indigenous human enterovirus species C in the viral polymerase coding region. J. Virol. 2005;79(20):12650–12657. - PMC - PubMed
    1. Atencio I.A., Belli B., Hobbs M., Cheng S.F., Villarreal L.P., Fan H. A model for mixed virus disease: co-infection with Moloney murine leukemia virus potentiates runting induced by polyomavirus (A2 strain) in Balb/c and NIH Swiss mice. Virology. 1995;212(2):356–366. - PubMed

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