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Case Reports
. 2010 Jan;110(1):16-20.

Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia

John V Ashurst  1 , Megan N Wasson, William Hauger, William T Fritz
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  • PMID: 20093649
Case Reports

Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia

John V Ashurst et al. J Am Osteopath Assoc. 2010 Jan.

Abstract

Dapsone is a leprostatic agent commonly prescribed for the treatment of patients with leprosy, malaria, and a variety of blistering skin diseases, including dermatitis herpetiformis. Methemoglobinemia, a potentially life-threatening condition in which the oxygen-carrying capacity of blood in body tissues is reduced, is a known adverse effect of dapsone use. The authors report a case of dapsone-induced methemoglobinemia observed in the emergency department during routine workup for contact dermatitis in a patient with celiac disease. The pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia are discussed.

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