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Case Reports
. 2010 Feb;115(2 Pt 2):434-436.
doi: 10.1097/AOG.0b013e3181c51ed0.

Epstein-Barr virus-associated uterine leiomyosarcoma in an adult lung transplant patient

Jan Sunde  1 , Shilpa Chetty-John, Oksana A Shlobin, Charles R Boice
Affiliations
Case Reports

Epstein-Barr virus-associated uterine leiomyosarcoma in an adult lung transplant patient

Jan Sunde et al. Obstet Gynecol. 2010 Feb.

Abstract

Background: Multiple viruses have been associated with carcinogenesis in solid-organ transplant patients. Although Epstein-Barr virus (EBV) has been associated with lymphomas in immunocompromised patients, an association with smooth muscle tumors recently has been described.

Case: An EBV immunoglobulin G-positive woman underwent bilateral lung transplant for sarcoidosis. She was placed on immunosuppression and prophylaxis for opportunistic infections. She presented 5 months later with an EBV-positive uterine leiomyosarcoma. Postoperative therapy included a decrease in immunosuppression and antiviral therapy. Recurrence was noted after 1 year; the patient developed sepsis while undergoing chemotherapy and declined further therapy.

Conclusion: Epstein-Barr virus-associated leiomyosarcoma can occur in the uterus in immunosuppressed patients.

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