Structural correlates of arterial endothelial permeability in the Evans blue model
- PMID: 200955
Item in Clipboard
Structural correlates of arterial endothelial permeability in the Evans blue model
Prog Biochem Pharmacol.
1977.
Abstract
Normal young pigs were injected intravenously with azo dye Evans blue, which is preferentially and consistently taken up by focal areas in the aorta known to be areas of enhanced permeability. Ferritin was intravenously injected into these animals, and its uptake was quantitated at the electron microscope level at 1, 5 and 15 min after administration. The number of vesicles, large inclusions or vacuoles, and junctions, both labelled and unlabelled, were counted in areas of normal and enhanced permeability. The results have revealed that the number of ferritin grains per vesicle is the same in both areas. However, the percentage of vesicles containing ferritin is significantly higher in areas of enhanced permeability.
Similar articles
-
Endothelial cell morphology in areas of in vivo Evans blue uptake in the aorta of young pigs. II. Ultrastructure of the intima in areas of differing permeability to proteins.Am J Pathol. 1977 Nov;89(2):313-34. Am J Pathol. 1977. PMID: 920777 Free PMC article.
-
Alteration of endothelial cell surface morphology after experimental aortic coarctation.Artery. 1980;8(3):267-74. Artery. 1980. PMID: 7213036
-
Evans blue dye: its accumulation in extracellular space in relation to endothelial cell basement membrane in normal an atherosclerotic areas of abdominal aorta.Arch Pathol Lab Med. 1982 Apr;106(4):186-91. Arch Pathol Lab Med. 1982. PMID: 6895990
-
Endothelial cell injury in early mild hypercholesterolemia.Prog Biochem Pharmacol. 1977;13:213-9. Prog Biochem Pharmacol. 1977. PMID: 928421
-
Modification in the transmural concentration of cholesterol and the transmural distribution of 131I-albumin in the aortas of pigs fed cholesterol: a preliminary report.Artery. 1983;12(1):24-32. Artery. 1983. PMID: 6205643
Cited by
-
Monitoring vascular permeability and remodeling after endothelial injury in a murine model using a magnetic resonance albumin-binding contrast agent.Circ Cardiovasc Imaging. 2015 Apr;8(4):e002417. doi: 10.1161/CIRCIMAGING.114.002417. Circ Cardiovasc Imaging. 2015. PMID: 25873720 Free PMC article.
-
Monocyte migration into the subendothelial space of a coculture of adult human aortic endothelial and smooth muscle cells.J Clin Invest. 1988 Dec;82(6):1853-63. doi: 10.1172/JCI113802. J Clin Invest. 1988. PMID: 3198759 Free PMC article.
-
Nuclear medicine and atherosclerosis.Eur J Nucl Med. 1990;17(3-4):160-78. doi: 10.1007/BF00811446. Eur J Nucl Med. 1990. PMID: 2279498 Review.
-
Molecular mechanisms responsible for the atheroprotective effects of laminar shear stress.Antioxid Redox Signal. 2009 Jul;11(7):1669-82. doi: 10.1089/ars.2009.2487. Antioxid Redox Signal. 2009. PMID: 19309258 Free PMC article. Review.
-
The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.Am J Pathol. 1981 May;103(2):181-90. Am J Pathol. 1981. PMID: 7234961 Free PMC article.