doi: 10.1016/j.bbr.2010.01.021.
Epub 2010 Jan 25.
Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
Affiliations
- PMID: 20097232
- DOI: 10.1016/j.bbr.2010.01.021
Item in Clipboard
Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
Behav Brain Res.
.
Free article
Abstract
The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.
Similar articles
-
Enhanced pronociception by amygdaloid group I metabotropic glutamate receptors in nerve-injured animals.Exp Neurol. 2009 Mar;216(1):66-74. doi: 10.1016/j.expneurol.2008.11.005. Epub 2008 Nov 25. Exp Neurol. 2009. PMID: 19094988
-
Pain-related behavior following REM sleep deprivation in the rat: influence of peripheral nerve injury, spinal glutamatergic receptors and nitric oxide.Brain Res. 2007 May 7;1148:105-12. doi: 10.1016/j.brainres.2007.02.040. Epub 2007 Feb 24. Brain Res. 2007. PMID: 17368427
-
Corticotropin-releasing factor in the rat amygdala differentially influences sensory-discriminative and emotional-like pain response in peripheral neuropathy.J Pain. 2010 Dec;11(12):1461-71. doi: 10.1016/j.jpain.2010.05.004. Epub 2010 Jul 10. J Pain. 2010. PMID: 20624690
-
[Neuronal mechanisms underlying pain-induced negative emotions].Brain Nerve. 2012 Nov;64(11):1241-7. Brain Nerve. 2012. PMID: 23131734 Review. Japanese.
-
Photopharmacological manipulation of amygdala metabotropic glutamate receptor mGlu4 alleviates neuropathic pain.Pharmacol Res. 2023 Jan;187:106602. doi: 10.1016/j.phrs.2022.106602. Epub 2022 Dec 15. Pharmacol Res. 2023. PMID: 36529205 Review.
Cited by
-
Central sensitization of the spino-parabrachial-amygdala pathway that outlasts a brief nociceptive stimulus.J Physiol. 2018 Jul 13;596(18):4457-73. doi: 10.1113/JP273976. Online ahead of print. J Physiol. 2018. PMID: 30004124 Free PMC article.
-
Neuroplasticity underlying the comorbidity of pain and depression.Neural Plast. 2015;2015:504691. doi: 10.1155/2015/504691. Epub 2015 Feb 25. Neural Plast. 2015. PMID: 25810926 Free PMC article. Review.
-
Differential effects of mGluR7 and mGluR8 activation on pain-related synaptic activity in the amygdala.Neuropharmacology. 2011 Dec;61(8):1334-44. doi: 10.1016/j.neuropharm.2011.08.006. Epub 2011 Aug 16. Neuropharmacology. 2011. PMID: 21854791 Free PMC article.
-
PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus.Mol Pain. 2023 Jan-Dec;19:17448069231202598. doi: 10.1177/17448069231202598. Mol Pain. 2023. PMID: 37699860 Free PMC article.
-
The role of hedonics in the Human Affectome.Neurosci Biobehav Rev. 2019 Jul;102:221-241. doi: 10.1016/j.neubiorev.2019.05.003. Epub 2019 May 6. Neurosci Biobehav Rev. 2019. PMID: 31071361 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
