Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Feb;10(2):131-44.
doi: 10.1038/nri2707.

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

Affiliations
Review

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function

Maria T Abreu. Nat Rev Immunol. 2010 Feb.

Erratum in

  • Nat Rev Immunol. 2010 Mar;10(3):215

Abstract

A single layer of epithelial cells lines the small and large intestines and functions as a barrier between commensal bacteria and the rest of the body. Ligation of Toll-like receptors (TLRs) on intestinal epithelial cells by bacterial products promotes epithelial cell proliferation, secretion of IgA into the gut lumen and expression of antimicrobial peptides. As described in this Review, this establishes a microorganism-induced programme of epithelial cell homeostasis and repair in the intestine. Dysregulation of this process can result in chronic inflammatory and over-exuberant repair responses, and it is associated with the development of colon cancer. Thus, dysregulated TLR signalling by intestinal epithelial cells may explain how colonic bacteria and inflammation promote colorectal cancer.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Gastroenterology. 2004 Feb;126(2):451-9 - PubMed
    1. Cell. 2004 Sep 17;118(6):671-4 - PubMed
    1. J Immunol. 2006 Apr 1;176(7):4275-83 - PubMed
    1. Mol Immunol. 2008 May;45(10):2929-36 - PubMed
    1. Nature. 2008 Oct 9;455(7214):804-7 - PubMed

MeSH terms

Substances

LinkOut - more resources