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. 1991 Mar 15;47(3):250-1.
doi: 10.1007/BF01958150.

N-ethylmaleimide antagonizes stress-induced gastric ulcers in rats

G P Garg  1 , C H Cho, C W Ogle
Affiliations

N-ethylmaleimide antagonizes stress-induced gastric ulcers in rats

G P Garg et al. Experientia. .

Abstract

N-ethylmaleimide (NEM) 10 or 25 mg/kg b.wt, given s.c. 20 min beforehand, dose-dependently and significantly antagonizes the severity of gastric glandular ulcers produced by restraint at 4 degrees C (stress) for 2 h. These findings suggest that reduced activity of endogenous nonprotein sulfhydryl substances in gastric tissue does not worsen stress-induced ulceration in rat stomachs, unlike the deleterious effect its depletion is claimed to have on ethanol-evoked gastric mucosal damage. Thus, decreased SH activity appears not to play a role in the aetiology of mucosal ulcers due to stress.

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