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. 2010 Jan-Feb;17(1):58-65.
doi: 10.3109/09286580903450353.

Overall diet quality and age-related macular degeneration

Martha P Montgomery  1 , Freya Kamel, Margaret A Pericak-Vance, Jonathan L Haines, Eric A Postel, Anita Agarwal, Marie Richards, William K Scott, Silke Schmidt
Affiliations

Overall diet quality and age-related macular degeneration

Martha P Montgomery et al. Ophthalmic Epidemiol. 2010 Jan-Feb.

Erratum in

  • Ophthalmic Epidemiol. 2010 Jun;17(3):177

Abstract

Purpose: To examine overall diet quality in relation to advanced age-related macular degeneration (AMD).

Methods: This case-control study identified 437 advanced AMD patients and 259 unrelated controls using stereoscopic color fundus photographs. Participants were predominantly non-Hispanic White men and women from North Carolina and Tennessee. A 97-item Block food frequency questionnaire was used to gather diet information, and overall diet quality was measured using the Healthy Eating Index (HEI) and Alternate Healthy Eating Index (AHEI).

Results: Participants in the highest quartile of diet quality had significantly reduced odds of AMD according to the AHEI score (0.54, 95% confidence interval 0.30-0.99) and non-significantly reduced odds of AMD according to the HEI (0.75, 0.41-1.38). Odds of AMD were also 51% lower in the highest quartile of fish intake compared to the lowest quartile (odds ratio = 0.49, 0.26-0.90).

Conclusions: We found that advanced AMD was significantly related to overall diet quality. The AHEI score may be a useful instrument for assessing AMD risk due to diet, and it could potentially be improved by incorporating more specific information regarding micronutrient intake.

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References

    1. Resnikoff S, Pascolini D, Etya'ale D, et al. Global data on visual impairment in the year 2002. Bull World Health Organ. 2004;82:844–851. - PMC - PubMed
    1. Seddon JM, Rosner B, Sperduto RD, et al. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol. 2001;119:1191–1199. - PubMed
    1. Smith W, Mitchell P, Leeder SR. Dietary fat and fish intake and age-related maculopathy. Arch Ophthalmol. 2000;118:401–404. - PubMed
    1. Cho E, Hung S, Willett WC, et al. Prospective study of dietary fat and the risk of age-related macular degeneration. Am J Clin Nutr. 2001;73:209–218. - PubMed
    1. Seddon JM, Cote J, Rosner B. Progression of age-related macular degeneration: association with dietary fat, transunsaturated fat, nuts, and fish intake. Arch Ophthalmol. 2003;121:1728–1737. - PMC - PubMed

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