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. 2010 Jun;40(6):867-74.
doi: 10.1111/j.1365-2222.2009.03439.x. Epub 2010 Jan 20.

Nasal eosinophilia: an indicator of eosinophilic inflammation in asthma

M M Amorim  1 , A Araruna, L B Caetano, A C Cruz, L L Santoro, A L G Fernandes
Affiliations

Nasal eosinophilia: an indicator of eosinophilic inflammation in asthma

M M Amorim et al. Clin Exp Allergy. 2010 Jun.

Erratum in

  • Clin Exp Allergy. 2010 Nov;40(11):1711

Abstract

Background: It is noteworthy that there is a clear clinical, epidemiological and pathophysiological association between upper and lower airway inflammation in rhinitis and asthma.

Objective: The aim of this study was to compare the eosinophil counts in induced sputum and nasal lavage fluids in asthma, checking their association and the accuracy of nasal eosinophilia as a predictor of sputum eosinophilia by a cross-sectional study.

Methods: The clinical evaluation, asthma control questionnaire (ACQ), pre- and post-bronchodilator spirometry, nasal and sputum sample was performed. The nasal eosinophilia was analysed by a receiver operating curve and logistic regression model.

Results: In 140 adults, the post-bronchodilator forced expiratory volume in 1 s (FEV(1)) did not differ between patients with or without sputum eosinophilia (0.18). After adjusted for upper airway symptoms, age, ACQ score and post-bronchodilator FEV(1), sputum eosinophilia was associated with 52 times increase in odds of nasal eosinophilia, whereas each 1% increase in bronchodilator response was associated with 7% increase in odds of nasal eosinophilia.

Conclusion: This study brings further evidence that upper airway diseases are an important component of the asthma syndrome. Furthermore, monitoring of nasal eosinophilia by quantitative cytology may be useful as a surrogate of sputum cytology in as a component of composite measurement for determining airway inflammation.

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