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Clinical Trial
. 2010 Jan 25;12(1):6.
doi: 10.1186/1532-429X-12-6.

Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease

Carmen Wing-Sze Chan  1 , Yok-Lam Kwong, Raymond Y Kwong, Chu-Pak Lau, Hung-Fat Tse
Affiliations
Clinical Trial

Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease

Carmen Wing-Sze Chan et al. J Cardiovasc Magn Reson. .

Abstract

Background: Recent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR).

Methods and results: We compared the interval changes of left ventricular ejection fraction (LVEF), myocardial perfusion reserve and the extent of myocardial scar by using late gadolinium enhancement CMR in 12 patients with severe CAD. CMR was performed at baseline and at 6 months after catheter-based direct endomyocardial autologous BM cell (n = 12) injection to viable ischaemic myocardium as guided by electromechanical mapping. In patients randomized to receive BM cell injection, there was significant decrease in percentage area of peri-infarct regions (-23.6%, P = 0.04) and increase in global LVEF (+9.0%, P = 0.02), the percentage of regional wall thickening (+13.1%, P= 0.04) and MPR (+0.25%, P = 0.03) over the target area at 6-months compared with baseline.

Conclusions: Direct endomyocardial implantation of autologous BM cells significantly improved global LVEF, regional wall thickening and myocardial perfusion reserve, and reduced percentage area of peri-infarct regions in patients with severe CAD.

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Figures

Figure 1
Figure 1
(A) The endocardial (LVEN) and epicardial (LVEP) borders at the end diastole of delay enhancement image were trace manually. The white arrows indicating the extension of transmural myocardial infarction shown up as area of LGE. (B) A computer-assisted semiautomatic technique was applied to quantify the %MDEperi-infarct. The computer algorithm then used the signal-intensity thresholds of >3 SDs and 2 to 3 SDs above the normal myocardial segment (REMT) to delineate the infarct core (LYMO1- red region) and peri-infarct area (LYMO 2-yellow region) respectively.
Figure 2
Figure 2
Treatment effect of bone marrow (BM) cells implantation on myocardial perfusion reserve in targeted and non-targeted regions in the BM group as determined by CMR. Data presented as mean ± SD (error bar).
Figure 3
Figure 3
Treatment effect of bone marrow cells (BM) implantation on percentage of total infarct area and peri-infarct area in the BM group as determined by CMR. Data presented as mean ± SD (error bar).
See this image and copyright information in PMC

References

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