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. 2010 Jan 25:7:18.
doi: 10.1186/1743-422X-7-18.

Hepatitis C virus infection in blood donors from the state of Puebla, Mexico

Francisca Sosa-Jurado  1 , Gerardo Santos-López, Belinda Guzmán-Flores, Julia I Ruiz-Conde, Daniel Meléndez-Mena, Martín T Vargas-Maldonado, Ygnacio Martínez-Laguna, Laura Contreras-Mioni, Verónica Vallejo-Ruiz, Julio Reyes-Leyva
Affiliations

Hepatitis C virus infection in blood donors from the state of Puebla, Mexico

Francisca Sosa-Jurado et al. Virol J. .

Abstract

Background: Worldwide, 130 million persons are estimated to be infected with HCV. Puebla is the Mexican state with the highest mortality due to hepatic cirrhosis. Therefore, it is imperative to obtain epidemiological data on HCV infection in asymptomatic people of this region. The objective of present study was to analyze the prevalence of antibodies and genotypes of hepatitis C virus (HCV) in blood donors from Puebla, Mexico.

Results: The overall prevalence was 0.84% (515/61553). Distribution by region was: North, 0.86% (54/6270); Southeast, 1.04% (75/7197); Southwest, 0.93% (36/3852); and Central, 0.79% (350/44234). Ninety-six donors were enrolled for detection and genotyping of virus, from which 37 (38.5%) were HCV-RNA positive. Detected subtypes were: 1a (40.5%), 1b (27.0%), mixed 1a/1b (18.9%), undetermined genotype 1 (5.4%), 2a (2.7%), 2b (2.7%), and mixed 1a/2a (2.7%). All recovered donors with S/CO > 39 were HCV-RNA positive (11/11) and presented elevated ALT; in donors with S/CO < 39 HCV-RNA, positivity was of 30.4%; and 70% had normal values of ALT. The main risk factors associated with HCV infection were blood transfusion and surgery.

Conclusions: HCV prevalence of donors in Puebla is similar to other Mexican states. The most prevalent genotype is 1, of which subtype 1a is the most frequent.

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Figures

Figure 1
Figure 1
Prevalence rates of anti-HCV blood donors during the studied period in the state of Puebla. Specific anti-HCV antibodies were detected using the AxSYM HCV 3.0 assay (Abbott Diagnostics). Bars represent the 95% confidence interval.
Figure 2
Figure 2
Distribution of prevalence rates of anti-HCV blood donors by region in the state of Puebla. The Central Region is known as "Angelopolis". Bars represent the 95% confidence interval.
Figure 3
Figure 3
Distribution of donors (%) according to anti-HCV (S/CO) values. Comparison of total versus recovered anti-HCV (+) donors.
Figure 4
Figure 4
HCV-RNA positivity in recovered blood donors grouped by anti-HCV S/CO ratio values.
See this image and copyright information in PMC

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