Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Mar;30(6):1300-2.
doi: 10.1128/MCB.01661-09. Epub 2010 Jan 25.

p32 (C1QBP) and cancer cell metabolism: is the Warburg effect a lot of hot air?

Chi V Dang  1
Affiliations
Comment

p32 (C1QBP) and cancer cell metabolism: is the Warburg effect a lot of hot air?

Chi V Dang. Mol Cell Biol. 2010 Mar.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Schematic of a cancer cell with adequate oxygen (left) depicts the activation of p32 by Myc as well as Myc target genes involved in ribosomal biogenesis and glucose, glutamine, and nucleotide metabolism. p32 is shown to contribute to mitochondrial oxidative phosphorylation. Cancer cells undergoing oxidative phosphorylation around the tumor blood vessel (right) via the oxidation of glucose and glutamine proliferate and migrate away from the tumor blood vessel into hypoxic regions. Within the hypoxic tumor microenvironment, where hypoxia-inducible factors (HIF) are activated, the Warburg effect may permit survival because glycolysis proceeds independently of oxygen. Lactate produced by hypoxic cells is shown to be recycled for oxidation by cells that undergo OXPHOS.
See this image and copyright information in PMC

Comment on

References

    1. Christofk, H. R., M. G. Vander Heiden, M. H. Harris, A. Ramanathan, R. E. Gerszten, R. Wei, M. D. Fleming, S. L. Schreiber, and L. C. Cantley. 2008. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452:230-233. - PubMed
    1. Dang, C. V. 2009. PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect. Sci. Signal. 2:pe75. - PubMed
    1. Dang, C. V., J. W. Kim, P. Gao, and J. Yustein. 2008. The interplay between MYC and HIF in cancer. Nat. Rev. Cancer 8:51-56. - PubMed
    1. Dang, C. V., A. Le, and P. Gao. 2009. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin. Cancer Res. 15:6479-6483. - PMC - PubMed
    1. Deberardinis, R. J., and T. Cheng. 2 November 2009. Q.'s next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene [Epub ahead of print.] doi: 10.1038/onc.2009.358. - DOI - PMC - PubMed

Publication types