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Randomized Controlled Trial
. 2010 Jan;23(1):34-8.
doi: 10.1097/01.ASW.0000363485.17224.26.

Randomized comparison of OASIS wound matrix versus moist wound dressing in the treatment of difficult-to-heal wounds of mixed arterial/venous etiology

Marco Romanelli  1 , Valentina Dini, Maria Stefania Bertone
Affiliations
Randomized Controlled Trial

Randomized comparison of OASIS wound matrix versus moist wound dressing in the treatment of difficult-to-heal wounds of mixed arterial/venous etiology

Marco Romanelli et al. Adv Skin Wound Care. 2010 Jan.

Abstract

Objective: In this study, a biological extracellular matrix was compared with a moist wound dressing to determine its effectiveness in the treatment of mixed arterial/venous and venous ulcers.

Methods: Patients were evaluated for complete wound healing, time to dressing change, and formation of granulation tissue.

Results: Extracellular matrix-treated ulcers achieved complete healing on average in 5.4 weeks as compared with 8.3 weeks for the control group treated with moist wound dressing (P = .02). At the primary time point evaluated (8 weeks), complete wound closure was achieved in 80% of extracellular matrix-treated ulcers compared with 65% of ulcers in the control group (P < .05). Statistically significant differences favoring the extracellular-matrix treatment group were also reported for time to dressing change (P < .05), and for percentage of granulation tissue formed (P < .05).

Conclusion: Overall, the biological extracellular matrix was more beneficial than moist wound dressings for the treatment of patients with mixed arterial/venous or venous ulcers.

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