Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Feb;26(1):85-9.
doi: 10.1007/s12264-010-0604-1.

Research advancement in immunopathogenesis of myasthenia gravis

Sha Huang  1 , Li-Ming Tan
Affiliations
Review

Research advancement in immunopathogenesis of myasthenia gravis

Sha Huang et al. Neurosci Bull. 2010 Feb.

Abstract
in English, Chinese

Myasthenia gravis (MG) is an autoimmune neuromuscular junction disease mediated by antibodies against the acetylcholine receptor (AChR). The etiology and immunopathogenesis of MG remain unclear. Recent research has shown the involvement of autoantibodies, lymphocytes, cytokines and chemokines, in the pathogenesis of MG. Systematic factors are also demonstrated, such as inheritance and endocrine. This review indicates the research development in immunopathogenesis of MG.

症肌无力是一种由抗乙酰胆碱受体的抗体介导的神经肌肉接头处的自身免疫病。 其发病机制尚未阐明。 自身抗体、 淋巴细胞免疫调节紊乱、 细胞因子表达失衡及系统因素在重症肌无力的发病机制中均起重要作用。 本综述旨在探讨重症肌无力的免疫学发病机制。

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Skeie G.O., Aarli J.A., Gilhus N.E. Titin and ryanodine receptor antibodies in myasthenia gravis. Acta Neurol Scand. 2006;S183:19–23. doi: 10.1111/j.1600-0404.2006.00608.x. - DOI - PubMed
    1. Maruta T., Yoshikawa H., Fukasawa S., Umeshita S., Inaoka Y., Edahiro S., et al. Autoantibody to dihydropyridine receptor in myasthenia gravis. J Neuroimmunol. 2009;208(1–2):125–129. doi: 10.1016/j.jneuroim.2009.01.001. - DOI - PubMed
    1. Tackenberg B., Kruth J., Bartholomaeus J.E., Schlegel K., Oertel W.H., Willcox N., et al. Clonal expansions of CD4+ B helper T cells in autoimmune myasthenia gravis. Eur J Immunol. 2007;37(3):849–863. doi: 10.1002/eji.200636449. - DOI - PubMed
    1. Ben-David H., Sharabi A., Dayan M., Sela M., Mozes E. The role of CD8+CD28+ regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand. Proc Natl Acad Sci U S A. 2007;104(44):17459–17464. doi: 10.1073/pnas.0708577104. - DOI - PMC - PubMed
    1. Bi Y.J., Liu G.W., Yang R.F. Th17 cell induction and immune regulatory effects. J Cell Physiol. 2007;211:273–278. doi: 10.1002/jcp.20973. - DOI - PubMed