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Review
. 2010 Mar 1;116(5):1165-76.
doi: 10.1002/cncr.24862.

Adult acute lymphoblastic leukemia: concepts and strategies

Stefan Faderl  1 , Susan O'Brien, Ching-Hon Pui, Wendy Stock, Meir Wetzler, Dieter Hoelzer, Hagop M Kantarjian
Affiliations
Review

Adult acute lymphoblastic leukemia: concepts and strategies

Stefan Faderl et al. Cancer. .

Abstract

Acute lymphoblastic leukemia (ALL), a clonal expansion of hematopoietic blasts, is a highly heterogeneous disease comprising many entities for which distinct treatment strategies are pursued. Although ALL is a success story in pediatric oncology, results in adults lag behind those in children. An expansion of new drugs, more reliable immunologic and molecular techniques for the assessment of minimal residual disease, and efforts at more precise risk stratification are generating new aspects of adult ALL therapy. For this review, the authors summarized pertinent and recent literature on ALL biology and therapy, and they discuss current strategies and potential implications of novel approaches to the management of adult ALL. Cancer 2010. (c) 2010 American Cancer Society.

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Conflict of interest statement

CONFLICT OF INTEREST DISCLOSURES

Supported by grant CA21765 from the National Institutes of Health and by the American Lebanese Syrian Associated Charities.

Figures

Figure 1
Figure 1
Flow cytometric diagnosis of acute lymphoblastic leukemia (ALL) is illustrated. MPO indicates myeloperoxidase; NSE, nonspecific esterase; c, cytoplasmic; s, surface Pos, positive; Neg, negative; AML, acute myeloid leukemia.
See this image and copyright information in PMC

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