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. 2010 Feb;53(2):222-6.
doi: 10.1097/QAI.0b013e3181b980d4.

Hepatitis C and the risk of kidney disease and mortality in veterans with HIV

Michael J Fischer  1 , Christina M Wyatt, Kirsha Gordon, Cynthia L Gibert, Sheldon T Brown, David Rimland, Maria C Rodriguez-Barradas, Amy C Justice, Chirag R Parikh; VACS Project Team
Affiliations

Hepatitis C and the risk of kidney disease and mortality in veterans with HIV

Michael J Fischer et al. J Acquir Immune Defic Syndr. 2010 Feb.

Abstract

Objectives: To examine the effect of hepatitis C virus (HCV) on the prevalence of chronic kidney disease (CKD) among veterans with HIV and to evaluate independent associations of HCV and CKD with mortality.

Methods: We studied a national cohort of HIV-infected patients receiving care through the Veterans Healthcare Administration from 1998 to 2004. CKD was defined as an estimated glomerular filtration rate [eGFR (mL/min/1.73 m2)] < 60. Poisson regression was used to assess relationships between CKD, HCV, and mortality.

Results: Among 23,155 HIV-infected veterans, 12% had CKD. Forty percent of the cohort was coinfected with HCV, and a higher proportion of coinfected subjects had CKD compared with monoinfected subjects (14% vs 11%, P < 0.001). During the median follow-up of 7.6 years, 37% of subjects died and a graduated increase in adjusted mortality rates occurred with lower levels of eGFR (P < 0.001). Adjusted mortality rates were consistently higher in HCV-coinfected subjects across all levels of eGFR (P < 0.001). HCV was independently associated with increased mortality (incidence rate ratio 1.23, 95% confidence interval 1.17-1.29).

Conclusions: CKD is prevalent in HIV-infected veterans and associated with substantially higher mortality. Compared with their monoinfected counterparts, veterans coinfected with HCV have significantly higher rates of CKD and mortality.

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Figures

FIGURE 1
FIGURE 1
Mortality rates by eGFR and coinfection with HCV in HIV+ VACS cohort. py, person-years.
See this image and copyright information in PMC

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