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. 2010 Jan;46(1):68-72.
doi: 10.3164/jcbn.09-55. Epub 2009 Dec 29.

Energy metabolism in Japanese patients with Crohn's disease

Masaya Sasaki  1 , Tomoko Johtatsu, Mika Kurihara, Hiromi Iwakawa, Toshihiro Tanaka, Tomoyuki Tsujikawa, Yoshihide Fujiyama, Akira Andoh
Affiliations

Energy metabolism in Japanese patients with Crohn's disease

Masaya Sasaki et al. J Clin Biochem Nutr. 2010 Jan.

Abstract

We investigated energy expenditure in hospitalized patients with Crohn's disease (CD), and determined optimal energy requirements for nutritional therapy. Sixteen patients (5 women and 11 men, mean age 36 year old, mean BMI 18.7 kg/m(2)) and 8 healthy volunteers were enrolled in this study. Measured resting energy expenditure (mREE) levels were determined by indirect calorimetry. The mREEs in CD patients were significantly higher than those of healthy controls (24.4 +/- 2.4 kcal/kg/day vs 21.3 +/- 1.7 kcal/kg/day). However, mREEs in CD patients were significantly lower than predicted REEs (pREEs) calculated by the Harris-Benedict equation (26.4 +/- 2.5 kcal/kg/day). Furthermore, mREE/pREE values were lower in undernourished patients than in well-nourished patients. CD patients had hyper-metabolic statuses evaluated by mREE/body weight, but increased energy expenditure did not contribute to weight loss in these patients. In conclusion, nutritional therapy with 25-30 kcal/ideal body weight/day (calculated by mREE x active factor) may be optimal for active CD patients, while higher energy intake values pose the risk of overfeeding.

Keywords: Crohn’s disease; indirect calorimetry; resting energy expenditure.

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Figures

Fig. 1
Fig. 1
Correlation between measured resting energy expenditure (mREE) by indirect calorimetry and predicted resting energy expenditure (pREE) calculated by the Harris-Benedict equation in CD patients (n = 16). There is a positive correlation between mREE and pREE in CD patients.
Fig. 2
Fig. 2
Comparison of resting energy expenditure measured by using indirect calorimetry (mREE) and predicted resting energy expenditure (pREE) calculated by Harris-Benedict equation in CD patients (n = 16). mREE is significantly lower than pREE in CD patients.
Fig. 3
Fig. 3
Correlation between resting mREE and respiratory quotient (RQ) in CD patients (n = 16). RQ in CD patients exhibited a positive correlation with mREE.
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