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. 2010 Mar 2;26(5):2995-8.
doi: 10.1021/la904375k.

Thermo-switching of the conformation of genomic DNA in solutions of poly(N-isopropylacrylamide)

Ning Chen  1 , Anatoly A Zinchenko, Satoru Kidoaki, Shizuaki Murata, Kenichi Yoshikawa
Affiliations

Thermo-switching of the conformation of genomic DNA in solutions of poly(N-isopropylacrylamide)

Ning Chen et al. Langmuir. .

Abstract

We used poly(N-isopropylacrylamide) (PNIPAM) to control the conformation of genomic DNA by changing the temperature of a reaction solution and studied the DNA transition at the level of single DNA molecules. With this method, the conformation of long genomic DNA can be readily and reversibly switched between a very compact condensate and an unfolded macromolecule.

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