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. 2010 Feb 24;132(7):2124-5.
doi: 10.1021/ja909583s.

Iridium-monodentate phosphoramidite-catalyzed asymmetric hydrogenation of substituted benzophenone N-H imines

Guohua Hou  1 , Ran Tao, Yongkui Sun, Xumu Zhang, Francis Gosselin
Affiliations

Iridium-monodentate phosphoramidite-catalyzed asymmetric hydrogenation of substituted benzophenone N-H imines

Guohua Hou et al. J Am Chem Soc. .

Abstract

Homogeneous asymmetric hydrogenation of unprotected benzophenone N-H imines 1a-r using Ir-(S)-N-benzyl-N-methyl-MonoPhos as a catalyst provides chiral amines 2a-r in 80-96% yield with enantioselectivities up to 98% ee (18 examples) for ortho-substituted substrates.

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