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Case Reports
. 2010 Feb;156(2):327-31.
doi: 10.1016/j.jpeds.2009.08.033.

Failure of resolution of portal fibrosis during omega-3 fatty acid lipid emulsion therapy in two patients with irreversible intestinal failure

Jason S Soden  1 , Mark A Lovell, Kristin Brown, David A Partrick, Ronald J Sokol
Affiliations
Case Reports

Failure of resolution of portal fibrosis during omega-3 fatty acid lipid emulsion therapy in two patients with irreversible intestinal failure

Jason S Soden et al. J Pediatr. 2010 Feb.

Abstract

Parenteral omega-3 fatty acid lipid emulsions have been evaluated for their potential role in reversing intestinal failure-associated liver disease. We report our experience using Omegaven in 2 patients with irreversible intestinal failure and intestinal failure-associated liver disease. Despite biochemical and histologic improvement in cholestasis, both patients had persisting, significant portal fibrosis on liver biopsy.

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