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. 2010 May;156(5):719-23, 723.e1.
doi: 10.1016/j.jpeds.2009.11.043. Epub 2010 Jan 27.

Birth weight, family history of diabetes, and metabolic syndrome in children and adolescents

Fernando Guerrero-Romero  1 , Celia Aradillas-García, Luis E Simental-Mendia, Elizabeth Monreal-Escalante, Esperanza de la Cruz Mendoza, Martha Rodríguez-Moran
Affiliations

Birth weight, family history of diabetes, and metabolic syndrome in children and adolescents

Fernando Guerrero-Romero et al. J Pediatr. 2010 May.

Abstract

Objective: To evaluate whether a coupled family history of diabetes (FHD) and low birth weight (LBW) or high birth weight (HBW) is associated with metabolic syndrome (MetS) in children and adolescents.

Study design: A total of 1262 children and adolescents age 7-15 years were randomly selected to enroll in this cross-sectional, community-based study.

Results: In the overall population, HBW (odds ratio [OR] = 1.4; 95% confidence interval [CI] = 1.2-10.9), but not LBW (OR = 0.97; 95% CI = 0.6-2.1), was significantly associated with MetS. In the group without FHD, HBW (OR = 1.730; 95% CI = 1.1-2.7), but not LBW (OR = 1.139; 95% CI = 0.7-23), was associated with MetS. In the group with FHD, both LBW (OR = 2.690; 95% CI = 1.4-15.1) and HBW (OR = 3.289; 95% CI = 1.3-30.6) were associated with MetS. Both LBW (OR = 4.710; 95% CI = 1.4-39.7) and HBW (OR = 3.127; 95% CI = 1.3-45.1) were associated with MetS in children and adolescents with FHD in the maternal branch but not in the paternal branch.

Conclusions: HBW or LBW, in combination with positive FHD in the maternal branch, are determinants of MetS.

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