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. 2010 Apr;48(4):1245-54.
doi: 10.1128/JCM.02386-09. Epub 2010 Jan 27.

Circulation of mumps virus genotypes in Spain from 1996 to 2007

J E Echevarría  1 , A Castellanos, J C Sanz, C Pérez, G Palacios, M V Martínez de Aragón, I Peña Rey, M Mosquera, F de Ory, E Royuela
Affiliations

Circulation of mumps virus genotypes in Spain from 1996 to 2007

J E Echevarría et al. J Clin Microbiol. 2010 Apr.

Abstract

Although the WHO recommends the use of genotyping as a tool for epidemiological surveillance for mumps, limited data on mumps virus (MV) genotype circulation that may be used to trace the patterns of virus spread are available. We describe the first complete series of data from Spain. The small hydrophobic region was sequenced from 237 MV-positive samples from several regions of Spain collected between 1996 and 2007. Six different genotypes were identified: A, C, D (D1), G (G1, G2), H (H1, H2), and J. Genotype H1 was predominant during the epidemic that occurred from 1999 to 2003 but was replaced by genotype G1 as the dominant genotype in the epidemic that occurred from 2005 to 2007. The same genotype G1 strain caused concomitant outbreaks in different parts of the world (the United States, Canada, and the United Kingdom). The remaining genotypes (genotypes A, C, D, and J) appeared in sporadic cases or small limited outbreaks. This pattern of circulation seems to reflect continuous viral circulation at the national level, despite the high rates of vaccine coverage.

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Figures

FIG. 1.
FIG. 1.
Circulation of different mumps virus genotypes in Spain in relation to the clinical declaration of mumps to the mandatory information system. Both the sequences obtained in this study and the sequences published previously were included: 4 sequences from reference , 10 sequences from reference , 1 sequences from reference , and 8 sequences from reference .
FIG. 2.
FIG. 2.
Phylogenetic relationships among mumps virus genotypes. The phylogenetic tree was obtained by Bayesian inference.
FIG. 3.
FIG. 3.
Phylogenetic relationships among genotype H strains. ▴, reference strains; •, strains detected during this study.
FIG. 4.
FIG. 4.
Phylogenetic relationships among genotype D strains. ▴, reference strains; •, strains detected during this study.
FIG. 5.
FIG. 5.
Phylogenetic relationships among genotype C strains. ▴, reference strains; •, strains detected during this study.
FIG. 6.
FIG. 6.
Phylogenetic relationships among genotype G strains. ▴, reference strains; •, strains detected during this study.
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