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. 2010 Mar;91(3):786-93.
doi: 10.3945/ajcn.2009.28870. Epub 2010 Jan 27.

Dietary, lifestyle, and clinical predictors of lipoprotein-associated phospholipase A2 activity in individuals without coronary artery disease

Ida J Hatoum  1 , Jeanenne J Nelson, Nancy R Cook, Frank B Hu, Eric B Rimm
Affiliations

Dietary, lifestyle, and clinical predictors of lipoprotein-associated phospholipase A2 activity in individuals without coronary artery disease

Ida J Hatoum et al. Am J Clin Nutr. 2010 Mar.

Abstract

Background: Elevated lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) may be positively associated with risk of coronary artery disease, yet little is known about potentially modifiable factors related to Lp-PLA(2).

Objective: The aim of this study was to determine dietary, lifestyle, and clinical measures associated with Lp-PLA(2) activity.

Design: We measured Lp-PLA(2) activity in 853 female participants of the Nurses' Health Study and 878 male participants of the Health Professionals Follow-Up Study who were free of cancer and cardiovascular disease. Multivariable linear regression models were used to assess the relation between potentially modifiable factors and Lp-PLA(2).

Results: The replacement of 5% of energy from carbohydrates with energy from protein was associated with 2.2 nmol . min(-1) . mL(-1) lower levels of Lp-PLA(2) (95% CI: -3.1, -0.4) activity, and every 15-g/d increase in alcohol consumption was associated with 4.4 nmol . min(-1) . mL(-1) lower levels of Lp-PLA(2) activity (95% CI: -6.4, -2.4). Smoking (beta = 10.2; 95% CI: 4.8, 15.5), being overweight (beta = 7.5; 95% CI: 3.6, 11.3), aspirin use (beta = 6.0; 95% CI: 2.1, 10.0), hypercholesterolemia (beta = 15.0; 95% CI: 11.3, 18.8), and age (beta = 2.5; 95% CI: 1.34, 3.74) were associated with elevated Lp-PLA(2) activity, whereas postmenopausal hormone use (beta = -15.8; 95% CI: -19.4, -12.1) and cholesterol medication use (beta = -9.6; 95% CI: -18.2, -1.1) were inversely associated.

Conclusion: We found that not smoking, use of postmenopausal hormones, having a body mass index (in kg/m(2)) < or =25, increased alcohol consumption, and increased protein consumption all represent potential modifiable factors that may favorably influence Lp-PLA(2) activity.

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Figures

FIGURE 1
FIGURE 1
Estimates and 95% CIs from a multivariable-adjusted linear regression model of modifiable characteristics associated with lipoprotein-associated phospholipase A2 (Lp-PLA2) activity among 853 women in the Nurses’ Health Study and 878 men in the Health Professionals Follow-Up Study. Multivariable-adjusted model linear regression model was adjusted for protein intake, alcohol intake, total caloric intake, age, past smoking, current smoking, BMI (in kg/m2) of 25–29.9, BMI ≥ 30, postmenopausal hormone (PMH) use (women only), aspirin use, history of high cholesterol, and cholesterol-lowering medication use among participants with a history of high cholesterol.
See this image and copyright information in PMC

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