Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms
- PMID: 20107228
- DOI: 10.1056/NEJMc0910063
Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms
Comment on
-
Recurring mutations found by sequencing an acute myeloid leukemia genome.N Engl J Med. 2009 Sep 10;361(11):1058-66. doi: 10.1056/NEJMoa0903840. Epub 2009 Aug 5. N Engl J Med. 2009. PMID: 19657110 Free PMC article.
Similar articles
-
Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms.Leukemia. 2010 May;24(5):1094-6. doi: 10.1038/leu.2010.52. Epub 2010 Apr 8. Leukemia. 2010. PMID: 20376084 No abstract available.
-
Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias.Cancer Res. 2010 Jan 15;70(2):447-52. doi: 10.1158/0008-5472.CAN-09-3783. Epub 2010 Jan 12. Cancer Res. 2010. PMID: 20068184 Free PMC article.
-
TET2, ASXL1, IDH1, IDH2, and c-CBL genes in JAK2- and MPL-negative myeloproliferative neoplasms.Ann Hematol. 2012 Apr;91(4):533-41. doi: 10.1007/s00277-011-1330-0. Epub 2011 Sep 9. Ann Hematol. 2012. PMID: 21904853
-
Disordered epigenetic regulation in the pathophysiology of myeloproliferative neoplasms.Curr Hematol Malig Rep. 2012 Mar;7(1):34-42. doi: 10.1007/s11899-011-0105-y. Curr Hematol Malig Rep. 2012. PMID: 22170482 Review.
-
Genetics of the myeloproliferative neoplasms.Curr Opin Hematol. 2011 Mar;18(2):117-23. doi: 10.1097/MOH.0b013e328343998e. Curr Opin Hematol. 2011. PMID: 21307773 Review.
Cited by
-
Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation.Neuro Oncol. 2012 Dec;14(12):1465-72. doi: 10.1093/neuonc/nos258. Epub 2012 Oct 22. Neuro Oncol. 2012. PMID: 23090985 Free PMC article.
-
IDH1 as a Cooperating Mutation in AML Arising in the Context of Shwachman-Diamond Syndrome.Front Oncol. 2019 Aug 14;9:772. doi: 10.3389/fonc.2019.00772. eCollection 2019. Front Oncol. 2019. PMID: 31475115 Free PMC article.
-
IDH1 and IDH2 mutations in myeloid neoplasms--novel paradigms and clinical implications.Haematologica. 2010 Oct;95(10):1623-7. doi: 10.3324/haematol.2010.030015. Haematologica. 2010. PMID: 20884716 Free PMC article. No abstract available.
-
Exploring the key genes and pathways in enchondromas using a gene expression microarray.Oncotarget. 2017 Jul 4;8(27):43967-43977. doi: 10.18632/oncotarget.16700. Oncotarget. 2017. PMID: 28410203 Free PMC article.
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.Cancer Cell. 2010 Mar 16;17(3):225-34. doi: 10.1016/j.ccr.2010.01.020. Epub 2010 Feb 18. Cancer Cell. 2010. PMID: 20171147 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous