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. 2010 Feb 14;46(6):931-3.
doi: 10.1039/b921630h. Epub 2009 Dec 23.

Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes

Craig S McKay  1 , Joseph Moran, John Paul Pezacki
Affiliations

Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes

Craig S McKay et al. Chem Commun (Camb). .

Abstract

Strain-promoted cycloadditions of nitrones with cyclooctynes (k(2) = 1.5 M(-1) s(-1) at 25 degrees C) are up to 25 times more rapid than comparable reactions of azides.

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