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Randomized Controlled Trial
. 2010 Apr;24(2):300-2.
doi: 10.1007/s00540-010-0869-6. Epub 2010 Jan 28.

Lidocaine pretreatment reduces the frequency and severity of myoclonus induced by etomidate

Fethi Gultop  1 , Taylan Akkaya, Nurdan Bedirli, Haluk Gumus
Affiliations
Randomized Controlled Trial

Lidocaine pretreatment reduces the frequency and severity of myoclonus induced by etomidate

Fethi Gultop et al. J Anesth. 2010 Apr.

Abstract

The objective of this study was to assess the effects of lidocaine on the incidence and severity of myoclonic movements induced by etomidate. Sixty patients were randomly assigned to receive either 20 mg lidocaine or saline (n = 30, each), 30 s before administration of etomidate (0.3 mg/kg). One minute after etomidate administration we assessed severity of myoclonus. Pretreatment with lidocaine significantly reduced both the incidence and severity of myoclonic movements. As a conclusion, lidocaine is an effective and safe drug to reduce the etomidate-induced myoclonus without significant side effects.

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