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Review
. 2008 Oct-Dec;1(4):376-82.

So many options but one choice: the human body prefers alpha-tocopherol. A matter of stereochemistry

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Review

So many options but one choice: the human body prefers alpha-tocopherol. A matter of stereochemistry

B Manolescu et al. J Med Life. 2008 Oct-Dec.

Abstract

alpha-Tocopherol belongs to the group of vitamin E vitamers. Recent years findings indicate that alpha-tocopherol is more than just a simple fat-soluble anti-oxidant as it was found that it can also regulate gene expression. From all vitamin E vitamers human body preferentially retains alpha-tocopherol, but the reasons for this preference are still elusive. Different studies indicated that human body, through the action of two hepatic proteins, alpha-tocopherol transfer protein (alpha-TTP) and cytochrome P450 4F2 (CYP4F2), is able to make subtle structural differences between different vitamin E forms. This is an example of stereochemistry used as a discrimination factor between molecules with different biological activities.

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Figures

Fig. 1
Fig. 1
Chemical structures of tocopherols and tocotrienols. The circles mark the three chiral centers in tocopherols (2, 4’, 8’).
Fig. 2
Fig. 2
α-Tocopherol acting as a chain-breaking anti-oxidant.
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